Iridium(III)-Catalyzed C-H Cyclization of Sulfoximines with Diazo Meldrum's Acids for the Synthesis of Cyclic Sulfoximines

被引：6

作者：

Han, Gi Uk ^{[1
]}

Kim, Suhui ^{[1
]}

Han, Sang Hoon ^{[1
]}

Maeng, Chanyoung ^{[1
]}

Ko, Gi Hoon ^{[1
]}

Lee, Kyungsup ^{[1
]}

Noh, Hee Chan ^{[1
]}

Lee, Phil Ho ^{[1
]}

机构：

[1] Kangwon Natl Univ, Dept Chem, Chunchon 24341, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 16期

基金：

新加坡国家研究基金会;

关键词：

RING-SYSTEMS; FUNCTIONALIZATION; NITROGEN; CARBON;

D O I：

10.1021/acs.joc.3c00984

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iridium(III)-catalyzed C-H cyclization of sulfoximineswithdiazo Meldrum's acid provided cyclic sulfoximines with a carbonylgroup in good to excellent yields. These compounds were easily convertedinto unsubstituted and arylated sulfoximines. Moreover, the vinyltriflates obtained from the cyclic sulfoximines underwent palladium(II)-catalyzedcross-coupling reactions with a variety of aryl, arylalkynyl, andheteroatom (N and S) nucleophiles, affording a wide range of monosubstitutedsulfoximines in high yields.

引用

页码：11702 / 11711

页数：10

共 53 条

[51] Emerging unconventional organic solvents for C-H bond and related functionalization reactions [J].