Effects of SGLT2 inhibitors on cardiac structure and function

被引：6

作者：

Novo, Giuseppina ^{[1
]}

Guarino, Tommaso ^{[1
]}

Di Lisi, Daniela ^{[1
]}

Biagioli, Paolo ^{[2
]}

Carluccio, Erberto ^{[2
]}

机构：

[1] Univ Palermo, Univ Hosp P Giaccone, Dept Hlth Promot Mother & Child Care, Internal Med & Med Special,Cardiol Unit, Palermo, Italy

[2] Univ Perugia, S Maria Misericordia Hosp, Cardiol & Cardiovasc Pathophysiol, Perugia, Italy

来源：

HEART FAILURE REVIEWS | 2023年 / 28卷 / 03期

关键词：

SGLT2; inhibitors; Heart failure; Left ventricle; Cardiac remodeling; Ejection fraction; Systolic function; Diastolic function; REDUCED EJECTION FRACTION; LEFT-VENTRICULAR HYPERTROPHY; HEART-FAILURE; EUROPEAN ASSOCIATION; AMERICAN SOCIETY; CHAMBER QUANTIFICATION; EMPAGLIFLOZIN; ECHOCARDIOGRAPHY; RECOMMENDATIONS; DAPAGLIFLOZIN;

D O I：

10.1007/s10741-022-10256-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SGLT2 inhibitors reduce cardiovascular death or hospitalization for heart failure, regardless of the presence or absence of diabetes in patients at high cardiovascular risk and in those with heart failure and reduced ejection fraction (HFrEF). In patients with HF and preserved EF, empagliflozin also showed favorable effects mainly related to the reduction of hospitalization for heart failure. These favorable effects are beyond the reduction of glycemic levels and mainly related to beneficial hemodynamic and anti-inflammatory effects of these drugs and improved cardiac energy metabolism. In this review, we aimed to evaluate the effects of SGLT2 inhibitor on cardiac remodeling and function, which is still incompletely clear.

引用

页码：697 / 707

页数：11

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