Grand Challenges at the Interface of Engineering and Medicine

被引：5

作者：

Subramaniam, Shankar ^{[1
,2
,3
]}

Akay, Metin ^{[4
,5
]}

Anastasio, Mark A. ^{[4
]}

Bailey, Vasudev ^{[4
]}

Boas, David ^{[6
,7
]}

Bonato, Paolo

Chilkoti, Ashutosh ^{[8
,9
]}

Cochran, Jennifer R. ^{[10
,11
,12
,13
]}

Colvin, Vicki ^{[14
,15
]}

Desai, Tejal A. ^{[16
]}

Duncan, James S. ^{[17
,18
]}

Epstein, Frederick H. ^{[19
,20
,21
]}

Fraley, Stephanie ^{[22
]}

Giachelli, Cecilia ^{[14
]}

Grande-Allen, K. Jane ^{[23
]}

Green, Jordan ^{[24
,25
]}

Guo, X. Edward ^{[17
]}

Hilton, Isaac B. ^{[26
,27
]}

Humphrey, Jay D. ^{[28
]}

Johnson, Chris R. ^{[29
,30
]}

Karniadakis, George ^{[31
]}

King, Michael R. ^{[32
]}

Kirsch, Robert F. ^{[33
]}

Kumar, Sanjay ^{[34
]}

Laurencin, Cato T. ^{[35
]}

Li, Song ^{[36
]}

Lieber, Richard L. ^{[37
,38
]}

Lovell, Nigel ^{[39
]}

Mali, Prashant ^{[40
]}

Margulies, Susan S. ^{[41
,42
]}

Meaney, David F. ^{[43
]}

Ogle, Brenda ^{[44
,45
,46
]}

Palsson, Bernhard ^{[22
,47
]}

Peppas, Nicholas A. ^{[48
,49
,50
,51
]}

Perreault, Eric J. ^{[52
,53
,54
]}

Rabbitt, Rick ^{[55
]}

Setton, Lori A. ^{[56
]}

Shea, Lonnie D. ^{[57
]}

Shroff, Sanjeev G. ^{[58
,59
]}

Shung, Kirk ^{[60
]}

Tolias, Andreas S. ^{[61
]}

van der Meulen, Marjolein C. H. ^{[62
]}

Varghese, Shyni ^{[63
]}

Vunjak-Novakovic, Gordana ^{[64
]}

White, John A. ^{[65
]}

Winslow, Raimond ^{[66
,67
]}

Zhang, Jianyi ^{[68
,69
,70
,71
]}

Zhang, Kun ^{[22
]}

Zukoski, Charles ^{[72
]}

Miller, Michael I. ^{[73
,74
,75
]}

机构：

[1] Univ Calif San Diego, Bioengn & Syst Biol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Bioengn Comp Sci & Engn, Cellular & Mol Med, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Nanoengn, La Jolla, CA 92093 USA

[4] Harvard Med Sch, Dept Phys Med & Rehabil, Spaulding Rehabil Hosp, Charlestown, MA USA

[5] Artis Ventures, San Francisco, CA USA

[6] Boston Univ, Coll Engn, Biomed Engn, Boston, MA USA

[7] Boston Univ, Coll Engn, Neurophoton Ctr, Boston, MA USA

[8] Duke Univ, Biomed Engn, Durham, NC USA

[9] Duke Univ, Dept Biomed Engn, Durham, NC USA

[10] Stanford Univ, Sch Med, Res, Stanford, CA USA

[11] Stanford Univ, Sch Engn, Res, Stanford, CA USA

[12] Stanford Univ, Shriram Ctr, Sch Med, Bioengn, Stanford, CA USA

[13] Stanford Univ, Shriram Ctr, Sch Engn, Bioengn, Stanford, CA USA

[14] Brown Univ, Chem, Providence, RI USA

[15] Brown Univ, Engn, Providence, RI USA

[16] Brown Univ, Engn, Providence, RI USA

[17] Yale Univ, Biomed Engn, New Haven, CT USA

[18] Yale Univ, Radiol & Biomed Imaging, New Haven, CT USA

[19] Sch Engn & Appl Sci, Biomed Engn, Charlottesville, VA USA

[20] Sch Engn & Appl Sci, Radiol & Med Imaging, Charlottesville, VA USA

[21] Sch Engn & Appl Sci, Res, Charlottesville, VA USA

[22] Univ Calif San Diego, Bioengn, La Jolla, CA USA

[23] Rice Univ, Dept Bioengn, Bioengn, Houston, TX USA

[24] Dept Biomed Engn, Biomed Engn, Baltimore, MD 21218 USA

[25] Dept Biomed Engn, Res & Translat, Baltimore, MD USA

[26] Rice Univ, Bioengn & BioSci, Houston, TX USA

[27] Biosci Res Collaborat, Dept Bioengn, Houston, TX USA

[28] Yale Univ, Biomed Engn, New Haven, CT USA

[29] Univ Utah, Comp Sci, Salt Lake City, UT USA

[30] Univ Utah, Bioengn, Salt Lake City, UT USA

[31] Brown Univ, Appl Maths & Engn, Providence, RI USA

[32] Stevenson Ctr 5824, Nashville, TN USA

[33] Case Western Reserve Univ, Biomed Engn, Cleveland, OH USA

[34] Calif Inst Quantitat Biosci, UC Berkeley, Berkeley, CA USA

[35] UConn, Cato T Laurencin Inst Regenerat Engn, Orthopaed Surg, Farmington, CT USA

[36] UCLA Samueli Sch Engn, Dept Bioengn, Los Angeles, CA USA

[37] Northwestern Univ, Shirley Ryan Abil Lab, Evanston, IL USA

[38] Northwestern Univ, Physiol & Biomed Engn, Evanston, IL USA

[39] Univ New South Wales, Grad Sch Biomed Engn, Sydney, NSW, Australia

[40] Univ Calif San Diego, Bioengn, La Jolla, CA USA

[41] Georgia Inst Technol, Biomed Engn, Atlanta, GA 30332 USA

[42] Emory Univ, Atlanta, GA USA

[43] Penn Engn, Philadelphia, PA USA

[44] Univ Minnesota Twin Cities, Dept Biomed Engn, Minneapolis, MN USA

[45] Univ Minnesota Twin Cities, Dept Pediat, Minneapolis, MN USA

[46] Univ Minnesota Twin Cities, Stem Cell Inst, Minneapolis, MN USA

[47] Univ Calif San Diego, Pediat, La Jolla, CA USA

[48] Univ Texas Austin, Engn, McKetta Dept Chem Engn, Dept Biomed Engn, Austin, TX USA

[49] Univ Texas Austin, Inst Biomat Drug Delivery & Regenerat Med, Austin, TX USA

[50] Univ Texas Austin, Dell Med Sch, McKetta Dept Chem Engn, Dept Biomed Engn,Dept Pediat, Austin, TX USA

来源：

IEEE OPEN JOURNAL OF ENGINEERING IN MEDICINE AND BIOLOGY | 2024年 / 5卷

关键词：

Genome-engineering; human function augmentation; immuno-engineering; precision medicine; digital twins; neuroimaging; tissue engineering; organs-on-chip; patient on a chip; stem cells; biomaterials; bioreactors; models of disease; organ regeneration; drug testing; heart; lung; bone; brain; brain-computer interfaces; artificial intelligence; machine learning; neuromodulation; synthetic biology; gene therapy; cell therapy; biomanufacturing; disease resistance;

D O I：

10.1109/OJEMB.2024.3351717

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistication with the ability to monitor human health in both non-invasive and invasive modes. The multiple scales at which human physiology can be interrogated provide a profound perspective on health and disease. We are at the nexus of creating "avatars" (herein defined as an extension of "digital twins") of human patho/physiology to serve as paradigms for interrogation and potential intervention. Motivated by the emergence of these new capabilities, the IEEE Engineering in Medicine and Biology Society, the Departments of Biomedical Engineering at Johns Hopkins University and Bioengineering at University of California at San Diego sponsored an interdisciplinary workshop to define the grand challenges that face biomedical engineering and the mechanisms to address these challenges. The Workshop identified five grand challenges with cross-cutting themes and provided a roadmap for new technologies, identified new training needs, and defined the types of interdisciplinary teams needed for addressing these challenges. The themes presented in this paper include: 1) accumedicine through creation of avatars of cells, tissues, organs and whole human; 2) development of smart and responsive devices for human function augmentation; 3) exocortical technologies to understand brain function and treat neuropathologies; 4) the development of approaches to harness the human immune system for health and wellness; and 5) new strategies to engineer genomes and cells.

引用

页码：1 / 13

页数：13