Pre-existing antibody allows for maturation of new B cells in 'recall' germinal centres

被引：0

作者：

Herb, Jake ^{[1
]}

Curotto de Lafaille, Maria ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, OxMS Preprint Journal Club, New York, NY 10029 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2024年 / 24卷 / 04期

关键词：

D O I：

10.1038/s41577-024-01012-w

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Re-exposure to a previously encountered antigen leads to robust antibody responses and the formation of 'recall' germinal centres. A preprint by Schiepers et al. shows that antibody feedback in these germinal centres ensures the maturation of naive B cells that can target escape epitopes.

引用

页码：234 / 234

页数：1

共 3 条

[1] Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting [J].

Mesin, Luka ;

Schiepers, Arien ;

Ersching, Jonatan ;

Barbulescu, Alexandru ;

Cavazzoni, Cecilia B. ;

Angelini, Alessandro ;

Okada, Takaharu ;

Kurosaki, Tomohiro ;

Victora, Gabriel D. .

CELL, 2020, 180 (01) :92-+

[2]

Schiepers Arien, 2023, bioRxiv, DOI 10.1101/2023.12.15.571936

[3] Molecular fate-mapping of serum antibody responses to repeat immunization [J].

Schiepers, Arien ;

van't Wout, Marije F. L. ;

Greaney, Allison J. J. ;

Zang, Trinity ;

Muramatsu, Hiromi ;

Lin, Paulo J. C. ;

Tam, Ying K. K. ;

Mesin, Luka ;

Starr, Tyler N. N. ;

Bieniasz, Paul D. D. ;

Pardi, Norbert ;

Bloom, Jesse D. D. ;

Victora, Gabriel D. D. .

NATURE, 2023, 615 (7952) :482-+

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