Therapeutic Approaches Targeting Ferroptosis in Cardiomyopathy

被引：2

作者：

Ruan, Yanqian ^{[1
]}

Zhang, Ling ^{[2
]}

Zhang, Lina ^{[1
]}

Zhu, Keyang ^{[1
]}

机构：

[1] Ningbo Univ, Sch Publ Hlth, Zhejiang Prov Key Lab Pathophysiol, Hlth Sci Ctr, Ningbo 315211, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Coll Life Sci, Hangzhou, Peoples R China

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 2025年 / 39卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Ferroptosis; Cardiomyopathy; Therapeutic approaches; Herbal medicine; DOXORUBICIN-INDUCED FERROPTOSIS; ISCHEMIA-REPERFUSION INJURY; CELL-DEATH; LIPID-PEROXIDATION; ISCHEMIA/REPERFUSION INJURY; IRON-METABOLISM; VITAMIN-E; GLUTATHIONE; HEART; MECHANISMS;

D O I：

10.1007/s10557-023-07514-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The term cardiomyopathy refers to a group of heart diseases that cause severe heart failure over time. Cardiomyopathies have been proven to be associated with ferroptosis, a non-apoptotic form of cell death. It has been shown that some small molecule drugs and active ingredients of herbal medicine can regulate ferroptosis, thereby alleviating the development of cardiomyopathy. This article reviews recent discoveries about ferroptosis, its role in the pathogenesis of cardiomyopathy, and the therapeutic options for treating ferroptosis-associated cardiomyopathy. The article aims to provide insights into the basic mechanisms of ferroptosis and its treatment to prevent cardiomyopathy and related diseases.

引用

页码：595 / 613

页数：19

共 169 条

[11] ENPP2 protects cardiomyocytes from erastin-induced ferroptosis [J].

Bai, Yu-Ting ;

Chang, Rong ;

Wang, Hua ;

Xiao, Feng-Jun ;

Ge, Ri-Li ;

Wang, Li-Sheng .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 499 (01) :44-51

[12] mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin [J].

Bayeva, Marina ;

Khechaduri, Arineh ;

Puig, Sergi ;

Chang, Hsiang-Chun ;

Patial, Sonika ;

Blackshear, Perry J. ;

Ardehali, Hossein .

CELL METABOLISM, 2012, 16 (05) :645-657

[13] Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction [J].

Behrouzi, Bita ;

Weyers, Jill J. ;

Qi, Xiuling ;

Barry, Jennifer ;

Rabadia, Vrajlal ;

Manca, Dino ;

Connelly, John ;

Spino, Michael ;

Wood, John C. ;

Strauss, Bradley H. ;

Wright, Graham A. ;

Ghugre, Nilesh R. .

BASIC RESEARCH IN CARDIOLOGY, 2020, 115 (03)

[14] The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis [J].

Bersuker, Kirill ;

Hendricks, Joseph M. ;

Li, Zhipeng ;

Magtanong, Leslie ;

Ford, Breanna ;

Tang, Peter H. ;

Roberts, Melissa A. ;

Tong, Bingqi ;

Maimone, Thomas J. ;

Zoncu, Roberto ;

Bassik, Michael C. ;

Nomura, Daniel K. ;

Dixon, Scott J. ;

Olzmann, James A. .

NATURE, 2019, 575 (7784) :688-+

[15] Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia [J].

Bhatt, Deepak L. ;

Steg, P. Gabriel ;

Miller, Michael ;

Brinton, Eliot A. ;

Jacobson, Terry A. ;

Ketchum, Steven B. ;

Doyle, Ralph T., Jr. ;

Juliano, Rebecca A. ;

Jiao, Lixia ;

Granowitz, Craig ;

Tardif, Jean-Claude ;

Ballantyne, Christie M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (01) :11-22

[16] Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation [J].

Bibli, Sofia-Iris ;

Hu, Jiong ;

Leisegang, Matthias S. ;

Wittig, Janina ;

Zukunft, Sven ;

Kapasakalidi, Andrea ;

Fisslthaler, Beate ;

Tsilimigras, Diamantis ;

Zografos, Georgios ;

Filis, Konstantinos ;

Brandes, Ralf P. ;

Papapetropoulos, Andreas ;

Sigala, Fragiska ;

Fleming, Ingrid .

REDOX BIOLOGY, 2020, 28

[17] Deferasirox for managing iron overload in people with thalassaemia [J].

Bollig, Claudia ;

Schell, Lisa K. ;

Ruecker, Gerta ;

Allert, Roman ;

Motschall, Edith ;

Niemeyer, Charlotte M. ;

Bassler, Dirk ;

Meerpohl, Joerg J. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2017, (08)

[18] Diagnostic, Prognostic, and Therapeutic Implications of Genetic Testing for Hypertrophic Cardiomyopathy [J].

Bos, J. Martijn ;

Towbin, Jeffrey A. ;

Ackerman, Michael J. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (03) :201-211

[19] The α6β4 integrin promotes resistance to ferroptosis [J].

Brown, Caitlin W. ;

Amante, John J. ;

Goel, Hira Lal ;

Mercurio, Arthur M. .

JOURNAL OF CELL BIOLOGY, 2017, 216 (12) :4287-4297

[20] Iron metabolism and iron disorders revisited in the hepcidin era [J].

Camaschella, Clara ;

Nai, Antonella ;

Silvestri, Laura .

HAEMATOLOGICA, 2020, 105 (02) :260-272

← 1 2 3 4 5 6 7 8 9 10 →