Therapeutic Approaches Targeting Ferroptosis in Cardiomyopathy

被引：2

作者：

Ruan, Yanqian ^{[1
]}

Zhang, Ling ^{[2
]}

Zhang, Lina ^{[1
]}

Zhu, Keyang ^{[1
]}

机构：

[1] Ningbo Univ, Sch Publ Hlth, Zhejiang Prov Key Lab Pathophysiol, Hlth Sci Ctr, Ningbo 315211, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Coll Life Sci, Hangzhou, Peoples R China

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 2025年 / 39卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Ferroptosis; Cardiomyopathy; Therapeutic approaches; Herbal medicine; DOXORUBICIN-INDUCED FERROPTOSIS; ISCHEMIA-REPERFUSION INJURY; CELL-DEATH; LIPID-PEROXIDATION; ISCHEMIA/REPERFUSION INJURY; IRON-METABOLISM; VITAMIN-E; GLUTATHIONE; HEART; MECHANISMS;

D O I：

10.1007/s10557-023-07514-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The term cardiomyopathy refers to a group of heart diseases that cause severe heart failure over time. Cardiomyopathies have been proven to be associated with ferroptosis, a non-apoptotic form of cell death. It has been shown that some small molecule drugs and active ingredients of herbal medicine can regulate ferroptosis, thereby alleviating the development of cardiomyopathy. This article reviews recent discoveries about ferroptosis, its role in the pathogenesis of cardiomyopathy, and the therapeutic options for treating ferroptosis-associated cardiomyopathy. The article aims to provide insights into the basic mechanisms of ferroptosis and its treatment to prevent cardiomyopathy and related diseases.

引用

页码：595 / 613

页数：19

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