Drug-drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects

被引：4

作者：

Yang, Dandan ^{[1
]}

Zhang, Wei ^{[1
]}

Ruan, Zourong ^{[1
]}

Jiang, Bo ^{[1
]}

Huang, Siqi ^{[2
]}

Wang, Jiaying ^{[1
]}

Zhao, Pengfei ^{[1
]}

Hu, Mengyue ^{[3
]}

Yan, Min ^{[2
]}

Lou, Honggang ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Ctr Clin Pharmacol, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 2, Dept Anesthesiol, Sch Med, Hangzhou, Zhejiang, Peoples R China

[3] Sichuan Haisco Pharmaceut Co Ltd, Chengdu, Peoples R China

来源：

CTS-CLINICAL AND TRANSLATIONAL SCIENCE | 2023年 / 16卷 / 10期

关键词：

GENERAL-ANESTHESIA; VALPROIC ACID; PROPOFOL; INDUCTION; INJECTION; EFFICACY; PAIN; DERIVATIVES; MULTICENTER; PREVENTION;

D O I：

10.1111/cts.13605

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Ciprofol (also known as HSK3486) is a promising intravenous anesthetic candidate derived from propofol and independently developed by Haisco Pharmaceutical Group Co., Ltd. (Chengdu, China). Compared with propofol, ciprofol has the potential to reduce the dose required and the associated risks. Ciprofol is extensively metabolized in vivo, and its interaction with other concurrently administered drugs during clinical application is worthy of attention. Therefore, an open-label, two-stage sequential study was performed in healthy subjects who received either a single administration of ciprofol injection or ciprofol injection after oral administration of sodium divalproex. The aim of the study was to evaluate the effects of sodium divalproex on ciprofol with respect to pharmacokinetics, pharmacodynamics, and safety, thus providing a basis for the rational clinical use of ciprofol and sodium divalproex.

引用

页码：1972 / 1981

页数：10

共 25 条

[1] Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects [J].

Bian, Yicong ;

Zhang, Hua ;

Ma, Sheng ;

Jiao, Yongyi ;

Yan, Pangke ;

Liu, Xiao ;

Ma, Shiping ;

Xiong, Yating ;

Gu, Zheming ;

Yu, Zhenwen ;

Huang, Chenrong ;

Miao, Liyan .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021, 87 (01) :93-105

[2] The efficacy and safety of ciprofol use for the induction of general anesthesia in patients undergoing gynecological surgery: a prospective randomized controlled study [J].

Chen, Ben-zhen ;

Yin, Xin-yu ;

Jiang, Li-hua ;

Liu, Jin-hui ;

Shi, Yan-yan ;

Yuan, Bi-ying .

BMC ANESTHESIOLOGY, 2022, 22 (01)

[3] Efficacy and safety of ciprofol for general anaesthesia induction in elderly patients undergoing major noncardiac surgery A randomised controlled pilot trial [J].

Ding, Yun-ying ;

Long, Yu-qin ;

Yang, Hao-tian ;

Zhuang, Kai ;

Ji, Fu-hai ;

Peng, Ke .

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2022, 39 (12) :960-963

[4] Reducing pain during propofol injection: The role of the solvent [J].

Doenicke, AW ;

Roizen, MF ;

Rau, J ;

Kellermann, W ;

Babl, J .

ANESTHESIA AND ANALGESIA, 1996, 82 (03) :472-474

[5] The effect of valproic acid on drug and steroid glucuronidation by expressed human UDP-glucuronosyltransferases [J].

Ethell, BT ;

Anderson, GD ;

Burchell, B .

BIOCHEMICAL PHARMACOLOGY, 2003, 65 (09) :1441-1449

[6] Efficacy of Pre-Treatment with Remimazolam on Prevention of Propofol-Induced Injection Pain in Patients Undergoing Abortion or Curettage: A Prospective, Double-Blinded, Randomized and Placebo-Controlled Clinical Trial [J].

Guan, Xuehai ;

Jiao, Ziyin ;

Gong, Xiaofang ;

Cao, Huiyu ;

Liu, Susu ;

Lan, Hongmeng ;

Huang, Xiaofang ;

Tan, Yanmeng ;

Xu, Bing ;

Lin, Chengxin .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 15 :4551-4558

[7] Participation of lipid transport and fatty acid metabolism in valproate sodium-induced hepatotoxicity in HepG2 cells [J].

Ji, Qiaoli ;

Shi, Xiaolian ;

Lin, Rong ;

Mao, Youhua ;

Zhai, Xiaogang ;

Lin, Qinqin ;

Zhang, Jiye .

TOXICOLOGY IN VITRO, 2010, 24 (04) :1086-1091

[8]

Kaeferstein Herbert, 2009, Leg Med (Tokyo), V11 Suppl 1, pS22, DOI 10.1016/j.legalmed.2009.01.037

[9] Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: A multi-centre, non-inferiority, randomized, controlled phase 3 clinical trial [J].

Li, Junxiang ;

Wang, Xiao ;

Liu, Jin ;

Wang, Xia ;

Li, Xiangkui ;

Wang, Yaping ;

Ouyang, Wen ;

Li, Jun ;

Yao, Shanglong ;

Zhu, Zhaoqiong ;

Guo, Qulian ;

Yu, Yonghao ;

Meng, Jinhai ;

Zuo, Yunxia .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2022, 131 (02) :138-148

[10] Efficacy and safety of ciprofol vs. propofol for the induction and maintenance of general anaesthesia A multicentre, single-blind, randomised, parallel-group, phase 3 clinical trial [J].

Liang, Peng ;

Dai, Meng ;

Wang, Xiao ;

Wang, Dongxin ;

Yang, Mengchang ;

Lin, Xuemei ;

Zou, Xiaohua ;

Jiang, Ke ;

Li, Yalan ;

Wang, Liangrong ;

Shangguan, Wangning ;

Ren, Jinghua ;

He, Hefan .

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2023, 40 (06) :399-406

← 1 2 3 →