Slow integrin-dependent migration organizes networks of tissue-resident mast cells

被引:19
作者
Kaltenbach, Lukas [1 ,2 ,3 ]
Martzloff, Paloma [1 ,2 ,3 ]
Bambach, Sarah K. [1 ,2 ,3 ]
Aizarani, Nadim [1 ,27 ]
Mihlan, Michael [1 ]
Gavrilov, Alina [1 ]
Glaser, Katharina M. [1 ,2 ,3 ]
Stecher, Manuel [1 ,2 ,3 ]
Thuenauer, Roland [4 ,5 ,6 ]
Thiriot, Aude [7 ,8 ,9 ]
Heger, Klaus [10 ]
Kierdorf, Katrin [11 ,12 ,13 ]
Wienert, Stephan [14 ,15 ,16 ,17 ]
von Andrian, Ulrich H. [7 ,8 ,9 ]
Schmidt-Supprian, Marc [18 ]
Nerlov, Claus [19 ]
Klauschen, Frederick [20 ,21 ,22 ]
Roers, Axel [23 ]
Bajenoff, Marc [24 ]
Gruen, Dominic [25 ,26 ]
Laemmermann, Tim [1 ]
机构
[1] Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany
[2] Int Max Planck Res Sch Immunobiol Epigenet & Meta, Freiburg, Germany
[3] Univ Freiburg, Fac Biol, Freiburg, Germany
[4] Ctr Struct Syst Biol CSSB, Adv Light & Fluorescence Microscopy Facil, Hamburg, Germany
[5] Univ Hamburg, Hamburg, Germany
[6] Leibniz Inst Virol LIV, Hamburg, Germany
[7] Harvard Med Sch, Dept Immunol, Boston, MA USA
[8] Harvard Med Sch, HMS Ctr Immune Imaging, Boston, MA USA
[9] MIT & Harvard, Ragon Inst MGH, Cambridge, MA USA
[10] Genentech Inc, Dept Canc Immunol, South San Francisco, CA USA
[11] Univ Freiburg, Inst Neuropathol, Fac Med, Freiburg, Germany
[12] Univ Freiburg, CIBSS Ctr Integrat Biol Signaling Studies, Freiburg, Germany
[13] Univ Freiburg, Ctr Basics NeuroModulat NeuroModulBasics, Fac Med, Freiburg, Germany
[14] Univ Med Berlin, Berlin, Germany
[15] Free Univ Berlin, Berlin, Germany
[16] Humboldt Univ, Berlin, Germany
[17] Berlin Inst Hlth, Inst Pathol, Berlin, Germany
[18] Tech Univ Munich, Sch Med, Ctr Translat Canc Res TranslaTUM, Inst Expt Hematol, Munich, Germany
[19] Univ Oxford, MRC Weatherall Inst Mol Med, John Radcliffe Hosp, MRC Mol Hematol Unit, Oxford, England
[20] Ludwig Maximilians Univ Munchen, Inst Pathol, Munich, Germany
[21] Berlin Inst Fdn Learning & Data BIFOLD, Berlin, Germany
[22] Charite Univ Med Berlin, Berlin, Germany
[23] Heidelberg Univ, Inst Immunol, Heidelberg, Germany
[24] Aix Marseille Univ, CNRS, Ctr Immunol Marseille Luminy, INSERM, Marseille, France
[25] Julius Maximilians Univ Wurzburg, Wurzburg Inst Syst Immunol, Max Planck Res Grp, Wurzburg, Germany
[26] Helmholtz Ctr Infect Res HZI, Helmholtz Inst RNA Based Infect Res HIRI, Wurzburg, Germany
[27] Friedrich Miescher Inst Biomed Res FMI, Basel, Switzerland
基金
欧洲研究理事会;
关键词
ADHESION; EXPRESSION; MICE; BETA-1-INTEGRIN; FIBRONECTIN; PLATELET; SURVIVAL; MEDIATE; TALIN; IGE;
D O I
10.1038/s41590-023-01493-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immune cell locomotion is associated with amoeboid migration, a flexible mode of movement, which depends on rapid cycles of actin polymerization and actomyosin contraction(1). Many immune cells do not necessarily require integrins, the major family of adhesion receptors in mammals, to move productively through three-dimensional tissue spaces(2,3). Instead, they can use alternative strategies to transmit their actin-driven forces to the substrate, explaining their migratory adaptation to changing external environments(4-6). However, whether these generalized concepts apply to all immune cells is unclear. Here, we show that the movement of mast cells (immune cells with important roles during allergy and anaphylaxis) differs fundamentally from the widely applied paradigm of interstitial immune cell migration. We identify a crucial role for integrin-dependent adhesion in controlling mast cell movement and localization to anatomical niches rich in KIT ligand, the major mast cell growth and survival factor. Our findings show that substrate-dependent haptokinesis is an important mechanism for the tissue organization of resident immune cells.
引用
收藏
页码:915 / +
页数:37
相关论文
共 62 条
  • [1] Differential expression analysis for sequence count data
    Anders, Simon
    Huber, Wolfgang
    [J]. GENOME BIOLOGY, 2010, 11 (10):
  • [2] Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
    Armulik, Annika
    Genove, Guillem
    Betsholtz, Christer
    [J]. DEVELOPMENTAL CELL, 2011, 21 (02) : 193 - 215
  • [3] A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors
    Buono, Mario
    Facchini, Raffaella
    Matsuoka, Sahoko
    Thongjuea, Supat
    Waithe, Dominique
    Luis, Tiago C.
    Giustacchini, Alice
    Besmer, Peter
    Mead, Adam J.
    Jacobsen, Sten Eirik W.
    Nerlov, Claus
    [J]. NATURE CELL BIOLOGY, 2016, 18 (02) : 157 - +
  • [4] Talin forges the links between integrins and actin
    Calderwood, DA
    Ginsberg, MH
    [J]. NATURE CELL BIOLOGY, 2003, 5 (08) : 694 - 697
  • [5] Cell-autonomous requirement for β1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice
    Carlson, Timothy R.
    Hu, Huiqing
    Braren, Rickmer
    Kim, Yung Hae
    Wang, Rong A.
    [J]. DEVELOPMENT, 2008, 135 (12): : 2193 - 2202
  • [6] Castello-Cros Remedios, 2009, V522, P275, DOI 10.1007/978-1-59745-413-1_19
  • [7] COLUMBO M, 1995, J IMMUNOL, V154, P6058
  • [8] Taking cell-matrix adhesions to the third dimension
    Cukierman, E
    Pankov, R
    Stevens, DR
    Yamada, KM
    [J]. SCIENCE, 2001, 294 (5547) : 1708 - 1712
  • [9] DASTYCH J, 1994, J IMMUNOL, V152, P213
  • [10] Transgenic mice with hematopoietic and lymphoid specific expression of Cre
    de Boer, J
    Williams, A
    Skavdis, G
    Harker, N
    Coles, M
    Tolaini, M
    Norton, T
    Williams, K
    Roderick, K
    Potocnik, AJ
    Kioussis, D
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (02) : 314 - 325