Carbon Dots: Opportunities and Challenges in Cancer Therapy

被引:56
作者
Bhattacharya, Tanima [1 ]
Shin, Gye Hwa [2 ]
Kim, Jun Tae [1 ,3 ]
机构
[1] Kyung Hee Univ, Dept Food & Nutr, Seoul 02447, South Korea
[2] Kunsan Natl Univ, Dept Food & Nutr, Gunsan 54150, South Korea
[3] Kyung Hee Univ, BioNanocomposite Res Ctr, Seoul 02447, South Korea
基金
新加坡国家研究基金会;
关键词
carbon dots; surface chemistry; cancer theranostic; bio-imaging; GRAPHENE QUANTUM DOTS; BLOOD-BRAIN-BARRIER; DRUG-DELIVERY; PHOTODYNAMIC THERAPY; BREAST-CANCER; FOLIC-ACID; IN-VITRO; FLUORESCENT-PROBES; NITROGEN; YIELD;
D O I
10.3390/pharmaceutics15031019
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recently, carbon dots (CDs) have been actively studied and reported for their various properties. In particular, the specific characteristics of carbon dots have been considered as a possible technique for cancer diagnosis and therapy. This is also a cutting-edge technology that offers fresh ideas for treating various disorders. Though carbon dots are still in their infancy and have not yet shown their value to society, their discovery has already resulted in some noteworthy advancements. The application of CDs indicates conversion in natural imaging. Photography using CDs has demonstrated extraordinary appropriateness in bio-imaging, the discovery of novel drugs, the delivery of targeted genes, bio-sensing, photodynamic therapy, and diagnosis. This review seeks to provide a comprehensive understanding of CDs, including their benefits, characteristics, applications, and mode of action. In this overview, many CD design strategies will be highlighted. In addition, we will discuss numerous studies on cytotoxic testing to demonstrate the safety of CDs. The current study will address the production method, mechanism, ongoing research, and application of CDs in cancer diagnosis and therapy.
引用
收藏
页数:22
相关论文
共 130 条
[1]   Facile Synthesis of Graphene Quantum Dots from 3D Graphene and their Application for Fe3+Sensing [J].
Ananthanarayanan, Arundithi ;
Wang, Xuewan ;
Routh, Parimal ;
Sana, Barindra ;
Lim, Sierin ;
Kim, Dong-Hwan ;
Lim, Kok-Hwa ;
Li, Jun ;
Chen, Peng .
ADVANCED FUNCTIONAL MATERIALS, 2014, 24 (20) :3021-3026
[2]   The role of photodynamic therapy on multidrug resistant breast cancer [J].
Aniogo, Eric Chekwube ;
George, Blassan Plackal Adimuriyil ;
Abrahamse, Heidi .
CANCER CELL INTERNATIONAL, 2019, 19 (1)
[3]   Tunable fluorescent carbon dots from biowaste as fluorescence ink and imaging human normal and cancer cells [J].
Atchudan, Raji ;
Kishore, Somasundaram Chandra ;
Gangadaran, Prakash ;
Edison, Thomas Nesakumar Jebakumar Immanuel ;
Perumal, Suguna ;
Rajendran, Ramya Lakshmi ;
Alagan, Muthulakshmi ;
Al-Rashed, Sarah ;
Ahn, Byeong-Cheol ;
Lee, Yong Rok .
ENVIRONMENTAL RESEARCH, 2022, 204
[4]   In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration [J].
Bao, Xin ;
Yuan, Ye ;
Chen, Jingqin ;
Zhang, Bohan ;
Li, Di ;
Zhou, Ding ;
Jing, Pengtao ;
Xu, Guiying ;
Wang, Yingli ;
Hola, Katerina ;
Shen, Dezhen ;
Wu, Changfeng ;
Song, Liang ;
Liu, Chengbo ;
Zboril, Radek ;
Qu, Songnan .
LIGHT-SCIENCE & APPLICATIONS, 2018, 7
[5]   Current status and prospects on chemical structure driven photoluminescence behaviour of carbon dots [J].
Barman, Monoj Kumar ;
Patra, Amitava .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS, 2018, 37 :1-22
[6]   Photophysical Properties of Doped Carbon Dots (N, P, and B) and Their Influence on Electron/Hole Transfer in Carbon Dots-Nickel (II) Phthalocyanine Conjugates [J].
Barman, Monoj Kumar ;
Jana, Bikash ;
Bhattacharyya, Santanu ;
Patra, Amitava .
JOURNAL OF PHYSICAL CHEMISTRY C, 2014, 118 (34) :20034-20041
[7]   Carbon dots, a powerful non-toxic support for bioimaging by fluorescence nanoscopy and eradication of bacteria by photothermia [J].
Belkahla, H. ;
Boudjemaa, R. ;
Caorsi, V ;
Pineau, D. ;
Curcio, A. ;
Lomas, J. S. ;
Decors, P. ;
Chevillot-Biraud, A. ;
Azais, T. ;
Wilhelm, C. ;
Randriamahazaka, H. ;
Hemadi, M. .
NANOSCALE ADVANCES, 2019, 1 (07) :2571-2579
[8]   Quantum Dots for In Vivo Small-Animal Imaging [J].
Bentolila, Laurent A. ;
Ebenstein, Yuval ;
Weiss, Shimon .
JOURNAL OF NUCLEAR MEDICINE, 2009, 50 (04) :493-496
[9]   Recent Advances in Molecular Imaging with Gold Nanoparticles [J].
Bouche, Mathilde ;
Hsu, Jessica C. ;
Dong, Yuxi C. ;
Kim, Johoon ;
Taing, Kimberly ;
Cormode, David P. .
BIOCONJUGATE CHEMISTRY, 2020, 31 (02) :303-314
[10]   High photoluminescence quantum efficiency in near infrared of CdS nanocrystals in glass phosphate matrix [J].
Camilo, Nilmar S. ;
Messias, Djalmir N. ;
Pilla, Viviane ;
Silva, Anielle C. A. ;
Dantas, Noelio O. ;
Andrade, Acacio A. .
JOURNAL OF LUMINESCENCE, 2022, 249