Avenues within the gut-liver-brain axis linking chronic liver disease and symptoms

被引：11
作者：
Nguyen, Henry H. [1 ,2 ]
Swain, Mark G. [3 ]
机构：
[1] Univ Calgary, Liver Unit, Snyder Inst Chron Dis, Cumming Sch Med,,Dept Med & Microbiol, Calgary, AB, Canada
[2] Univ Calgary, Liver Unit, Snyder Inst Chron Dis, Cumming Sch Med,Dept Immunol & Infect Dis, Calgary, AB, Canada
[3] Univ Calgary, Liver Unit, Snyder Inst Chron Dis, Cumming Sch Med,Dept Med, Calgary, AB, Canada
来源：
FRONTIERS IN NEUROSCIENCE | 2023年 / 17卷
关键词：
microbiome; neural pathways; host immune system; metabolites; sickness behavior; fatigue; depression; social withdrawal; PRIMARY BILIARY-CIRRHOSIS; CENTRAL-NERVOUS-SYSTEM; MIDDLE-AGED ADULTS; C VIRUS-INFECTION; QUALITY-OF-LIFE; SICKNESS BEHAVIOR; MICROBIOTA; MICROGLIA; FATIGUE; IMPACT;
D O I：
10.3389/fnins.2023.1171253
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Symptoms of fatigue, social withdrawal and mood disturbances are commonly encountered in patients with chronic liver disease and have a detrimental effect on patient quality of life. Treatment options for these symptoms are limited and a current area of unmet medical need. In this review, we will evaluate the potential mechanistic avenues within the gut-liver-brain axis that may be altered in the setting of chronic liver disease that drive the development of these symptoms. Both clinical and pre-clinical studies will be highlighted as we discuss how perturbations in host immune response, microbiome, neural responses, and metabolites composition can affect the central nervous system.
引用
收藏
页数：8
相关论文
共 96 条
[1]   Microbiome-microglia connections via the gut-brain axis [J].
Abdel-Haq, Reem ;
Schlachetzki, Johannes C. M. ;
Glass, Christopher K. ;
Mazmanian, Sarkis K. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2019, 216 (01) :41-59
[2]   Chronic Liver Diseases and the Microbiome-Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease [J].
Acharya, Chathur ;
Bajaj, Jasmohan S. .
GASTROENTEROLOGY, 2021, 160 (02) :556-572
[3]   The gut-liver axis in liver disease: Pathophysiological basis for therapy [J].
Albillos, Agustin ;
de Gottardi, Andrea ;
Rescigno, Maria .
JOURNAL OF HEPATOLOGY, 2020, 72 (03) :558-577
[4]   Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance [J].
Albillos, Agustin ;
Lario, Margaret ;
Alvarez-Mon, Melchor .
JOURNAL OF HEPATOLOGY, 2014, 61 (06) :1385-1396
[5]  
Alexander KS., 2018, NONALCOHOLIC FATTY L, DOI [10.1371/journal.pone.0194153, DOI 10.1371/JOURNAL.PONE.0194153]
[6]   ADAM Metalloproteinase Domain 17 Regulates Cholestasis-Associated Liver Injury and Sickness Behavior Development in Mice [J].
Almishri, Wagdi ;
Swain, Liam A. ;
D'Mello, Charlotte ;
Le, Tyson S. ;
Urbanski, Stefan J. ;
Nguyen, Henry H. .
FRONTIERS IN IMMUNOLOGY, 2022, 12
[7]   Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders [J].
Aron-Wisnewsky, Judith ;
Vigliotti, Chloe ;
Witjes, Julia ;
Le, Phuong ;
Holleboom, Adriaan G. ;
Verheij, Joanne ;
Nieuwdorp, Max ;
Clement, Karine .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2020, 17 (05) :279-297
[8]   Alcohol, liver disease and the gut microbiota [J].
Bajaj, Jasmohan S. .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2019, 16 (04) :235-246
[9]   Fecal Microbiota Transplant From a Rational Stool Donor Improves Hepatic Encephalopathy: A Randomized Clinical Trial [J].
Bajaj, Jasmohan S. ;
Kassam, Zain ;
Fagan, Andrew ;
Gavis, Edith A. ;
Liu, Eric ;
Cox, I. Jane ;
Kheradman, Raffi ;
Heuman, Douglas ;
Wang, Jessica ;
Gurry, Thomas ;
Williams, Roger ;
Sikaroodi, Masoumeh ;
Fuchs, Michael ;
Alm, Eric ;
John, Binu ;
Thacker, Leroy R. ;
Riva, Antonio ;
Smith, Mark ;
Taylor-Robinson, Simon D. ;
Gillevet, Patrick M. .
HEPATOLOGY, 2017, 66 (06) :1727-1738
[10]  
Bajaj Jasmohan S., 2021, RANDOMIZED CLIN TRIA, DOI [10.1002/hep.31496?casa_token=3manPtslG2cAAAAA:4RzxJjPEUWKG9X3wZhHPSzN99XPQIrtJTd-MSNFOQA-5Ap0zuKpFJxdxUikZyPd-YFIog_2J8Akp0ZPm, DOI 10.1002/HEP.31496?CASA_TOKEN=3MANPTSLG2CAAAAA:4RZXJJPEUWKG9X3WZHHPSZN99XPQIRTJTD-MSNFOQA-5AP0ZUKPFJXDXUIKZYPD-YFIOG_2J8AKP0ZPM]
12345678910