Evaluation of the Polysaccharide "Immeran" Activity in Syrian hamsters' Model of SARS-CoV-2

被引：0
作者：
Generalova, Liubov Viktorovna [1 ]
Laryushkin, Denis Pavlovich [2 ]
Leneva, Irina Anatolievna [3 ]
Ivanina, Anna Valerievna [3 ]
Trunova, Galina Vladimirovna [4 ]
Dolinnyi, Sergei Vladimirovich [1 ]
Generalov, Evgenii Aleksandrovich [5 ]
机构：
[1] Peoples Friendship Univ Russia, RUDN Univ, Fac Med, Moscow 117198, Russia
[2] Russian Acad Sci, Pushchino Sci Ctr Biol Res, Fed Res Ctr, Inst Cell Biophys, Pushchino 142290, Russia
[3] Mechnikov Res Inst Vaccines & Sera, Dept Virol, Moscow 105064, Russia
[4] Natl Med Res Radiol Ctr FSBI NMRRC, Minist Hlth Russian Federat, PA Hertsen Moscow, Fed State Budgetary Inst,Oncol Res Inst, Moscow 125284, Russia
[5] Lomonosov Moscow State Univ, Fac Phys, Moscow 119991, Russia
来源：
VIRUSES-BASEL | 2024年 / 16卷 / 03期
关键词：
Immeran; polysaccharide; Solanum tuberosum L; SARS-CoV-2; COVID-19; Syrian hamsters; respiratory disease; MULTICENTER; FAVIPIRAVIR; COVID-19;
D O I：
10.3390/v16030423
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
COVID-19 is a highly contagious respiratory disease with a high number of lethal cases in humans, which causes the need to search for new therapeutic agents. Polysaccharides could be one of the prospective types of molecules with a large variety of biological activities, especially antiviral. The aim of this work was to study the specific antiviral activity of the drug "Immeran" on a model of a new coronavirus infection SARS-CoV-2 in hamsters. Based on the second experiment, intraperitoneal treatment with the drug according to a treatment regimen in doses of 500 and 1000 mu g/kg (administration after an hour, then once a day every other day, a total of 3 administrations) was effective, reliably suppressing the replication of the virus in the lungs and, at a dose of 1000 mu g/kg, prevented weight loss in animals. In all cases, the treatment stimulated the formation of virus-neutralizing antibodies to the SARS-CoV-2 virus, which suggests that the drug possesses adjuvant properties.
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页数：15
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