Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?

被引：10

作者：

Chapela, Sebastian Pablo ^{[1
,2
]}

Simancas-Racines, Alison ^{[3
,4
]}

Ceriani, Florencia ^{[5
]}

Martinuzzi, Andres Luciano Nicolas ^{[6
,7
]}

Russo, Maria Paula ^{[8
]}

Zambrano, Ana Karina ^{[9
]}

Simancas-Racines, Daniel ^{[10
]}

Verde, Ludovica ^{[11
]}

Muscogiuri, Giovanna ^{[12
,13
]}

Katsanos, Christos S. ^{[14
]}

Frias-Toral, Evelyn ^{[15
]}

Barrea, Luigi ^{[16
]}

机构：

[1] Univ Buenos Aires, Fac Med, Dept Bioquim Humana, Buenos Aires, Argentina

[2] Hosp Britan Buenos Aires, Equipo Soporte Nutr, Buenos Aires, Argentina

[3] Univ Tecn Cotopaxi, Fac Ciencias Agr & Recursos Nat, Carrera Med Vet, Latacunga 050108, Ecuador

[4] Univ UTE, Fac Vet & Agron, Ctr Invest Salud Publ & Epidemiol Clin CISPEC, Santo Domingo, Ecuador

[5] Univ Republ Uruguay, Escuela Nutr, Montevideo, Uruguay

[6] Nutrihome, Buenos Aires, Argentina

[7] Univ Nacl Comahue, Fac Med, Buenos Aires, Argentina

[8] Hosp Italiano Buenos Aires, Serv Clin Med, Buenos Aires, Argentina

[9] Univ UTE, Fac Ciencias Salud Eugenio Espejo, Ctr Invest Genet & Genomica, Quito, Ecuador

[10] Univ UTE, Fac Ciencias Salud Eugenio Espejo, Ctr Invest Salud Publ & Epidemiol Clin CISPEC, Quito 170129, Ecuador

[11] Univ Naples Federico II, Dept Publ Hlth, Via Sergio Pansini 5, I-80131 Naples, Italy

[12] Univ Napoli Federico II, Dipartimento Med Clin & Chirurg, Unita Endocrinol Diabetol & Androl, Via Sergio Pansini 5, I-80131 Naples, Italy

[13] Univ Federico II, Cattedra Unesco Educ Salute E Allo Sviluppo Sosten, I-80131 Naples, Italy

[14] Arizona State Univ, Sch Life Sci, Tempe, AZ 85259 USA

[15] Univ Espiritu Santo, Sch Med, Samborondon 0901952, Ecuador

[16] Univ Telematica Pegaso, Dipartimento Benessere Nutr & Sport, Ctr Direzionale Isola F2,Via Porzio, I-80143 Naples, Italy

来源：

CURRENT NUTRITION REPORTS | 2024年 / 13卷 / 02期

关键词：

Very low-calorie ketogenic diet; Hypothyroidism; Obesity; Triiodothyronine; Thyrotropin; Thyroxine; RESTING METABOLIC-RATE; BODY-COMPOSITION; SUBCLINICAL HYPOTHYROIDISM; INSULIN-RESISTANCE; WEIGHT; FAT; ASSOCIATION; THYROTROPIN; CHILDREN; HORMONES;

D O I：

10.1007/s13668-024-00528-w

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Purpose of Review This review aims to explore in-depth the different aspects of the association between very low-calorie ketogenic diet (VLCKD), obesity and obesity-related thyroid dysfunction.Recent Findings The VLCKD, proposed as a non-pharmacological strategy for the management of certain chronic diseases, is becoming increasingly popular worldwide. Initially used to treat epilepsy, it has been shown to be effective in controlling body weight gain and addressing various pathophysiological conditions. Research has shown that a low-calorie, high-fat diet can affect thyroid hormone levels. Weight loss can also influence thyroid hormone levels. Studies have suggested that long-term use of VLCKD for refractory epilepsy may be related to the development of hypothyroidism, with an effect seen in various populations. In particular, women with obesity following VLCKD tend to have reduced T3 levels.Summary We propose further research to unravel the underlying mechanisms linking VLCKD to obesity and obesity-related thyroid dysfunction.

引用

页码：194 / 213

页数：20

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