Oxocarbon Acids and their Derivatives in Biological and Medicinal Chemistry

被引：1
作者：
Ratto, Amanda [1 ]
Honek, John F. [1 ,2 ]
机构：
[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada
[2] Univ Waterloo, Dept Chem, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada
来源：
CURRENT MEDICINAL CHEMISTRY | 2024年 / 31卷 / 10期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Deltic acid; squaric; croconic; rhodizonic; oxocarbon acids; bioisosteres; HISTAMINE H-2-RECEPTOR ANTAGONIST; BACTERIAL LECTIN FIMH; AMINO SQUARIC ACIDS; RHODIZONIC ACID; CROCONIC ACID; DELTIC ACID; PHOTOTHERMAL THERAPY; SQUARAINE DYES; SUBSTITUTED CYCLOBUTENEDIONES; OLIGODEOXYNUCLEOTIDE ANALOGS;
D O I：
10.2174/0929867330666230313141452
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The biological and medicinal chemistry of the oxocarbon acids 2,3-dihydroxycycloprop-2-en-1-one (deltic acid), 3,4-dihydroxycyclobut-3-ene-1,2-dione (squaric acid), 4,5-dihydroxy-4-cyclopentene-1,2,3-trione (croconic acid), 5,6-dihydroxy-cyclohex-5-ene-1,2,3,4-tetrone (rhodizonic acid) and their derivatives is reviewed and their key chemical properties and reactions are discussed. Applications of these compounds as potential bioisosteres in biological and medicinal chemistry are examined. Reviewed areas include cell imaging, bioconjugation reactions, antiviral, antibacterial, anticancer, enzyme inhibition, and receptor pharmacology.
引用
收藏
页码：1172 / 1213
页数：42
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