Relationships between CD34-, CD105-and bcl-2-Expression Levels and Contrast-Enhanced Ultrasound-Based Differential Diagnosis of Adnexal Tumours

被引：0

作者：

Szymanski, Marek ^{[1
,2
,3
]}

Florczyk, Iwona ^{[4
,5
]}

Janicki, Radoslaw ^{[1
,3
]}

Bernard, Piotr ^{[1
]}

Domaracki, Piotr ^{[1
]}

Brycht, Lukasz ^{[1
,6
]}

Szyca, Robert ^{[7
]}

Szymanska, Angelika ^{[3
,8
]}

Paniutycz, Julia ^{[9
]}

机构：

[1] 10th Mil Res Hosp & Polyclin, IPHC, Clin Gynaecol Oncol Gynaecol & Gynaecol Endocrinol, Powstancow Warszawy Str 5, PL-85681 Bydgoszcz, Poland

[2] Univ Torun, Univ Hosp 2, Coll Medicum Bydgoszcz, Nicolaus Copernicus,Dept Obstet Female Pathol & On, Ujejskiego St 75, PL-85168 Bydgoszcz, Poland

[3] NZOZ Ctr Medyczne Genesis Clin Infertil Treatment, Waleniowa Str 24, PL-85435 Bydgoszcz, Poland

[4] Independent Publ Hlth Care, Dept Internal Med, Tadeusza Kosciuszki 6, PL-88300 Mogilno, Poland

[5] Individual Med Practice Iwona Florczyk, Wesolowskich 5-3, PL-88300 Mogilno, Poland

[6] Specialist Hosp Wloclawek, Dept Gen & Oncol Surg, 49 Wieniecka St, PL-87800 Wloclawek, Poland

[7] 10th Mil Res Hosp & Polyclin, Clin Surg & Oncol Surg, IPHC, PL-85681 Bydgoszcz, Poland

[8] Med Univ Poznan, Fac Med, PL-61701 Poznan, Poland

[9] Multispecial City Hosp Bydgoszcz, Gynecol Obstet & Pregnancy Pathol Dept, 19 Szpitalna St, PL-85172 Bydgoszcz, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 23期

关键词：

ultrasonography; ovarian cancer; contrast-enhanced ultrasound; adnexal tumors; CEUS; CD34; CD105; bcl-2; OVARIAN-CANCER; SONOGRAPHY; BENIGN; MANAGEMENT; EXPRESSION; US;

D O I：

10.3390/jcm12237372

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The relationships between CEUS parameters of adnexal tumours and postoperative immunohistochemical assessments of CD34, CD105 and bcl-2 were analysed. This study aimed to investigate whether contrast-enhanced ultrasonography (CEUS) parameters depend on the microvascular density of the tumour lesion found after surgery. Fifty-one patients with a diagnosis of adnexal tumours were included in this single-centre, prospective study. Participants underwent preoperative CEUS (contrast-enhanced ultrasound). Colour Doppler enhancement characterisation parameters (Ystart, Ymax and S) were determined. Immunohistochemical examination of histological specimens of the adnexal lesions was then carried out to determine the expression levels of the CD34, CD105 and bcl-2 proteins. Relationships between the aforementioned parameters were investigated. No significant statistical correlations were observed between CD34, CD105 and bcl2 expression levels and CEUS parameters, independently of whether the operated lesion was malignant or benign. Transvaginal CEUS is diagnostic for the detection of pathological neoplastic vascularisation of an adnexal lesion independent of the density of microcapillaries found postoperatively.

引用

页数：11