Syncytin-1, syncytin-2 and suppressyn in human health and disease

被引：9
作者：
Priscakova, Petra [1 ]
Svoboda, Michal [1 ]
Feketova, Zuzana [1 ]
Hutnik, Juraj [1 ]
Repiska, Vanda [1 ]
Gbelcova, Helena [1 ]
Gergely, Lajos [1 ]
机构：
[1] Comenius Univ, Inst Med Biol Genet & Clin Genet, Fac Med, Sasinkova 4, Bratislava 81108, Slovakia
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2023年 / 101卷 / 12期
关键词：
Syncytin-1; Syncytin-2; Suppressyn; HERVs; Preeclampsia; Gestational trophoblastic disease; HUMAN ENDOGENOUS RETROVIRUSES; HUMAN PLACENTA; ENVELOPE GLYCOPROTEIN; HERV-W; MULTIPLE-SCLEROSIS; ENV GLYCOPROTEIN; EXPRESSION; PROTEIN; PREECLAMPSIA; RECEPTOR;
D O I：
10.1007/s00109-023-02385-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In this review, we summarized the results of experimental and clinical studies about three human endogenous retroviruses and their products-syncytin-1, syncytin-2, and suppressyn in human physiology and pathophysiology. We summed up the described connection with various pathological processes and diseases, mainly with pregnancy-induced hypertensive diseases such as preeclampsia, oncogenesis, gestational trophoblastic disease, and multiple sclerosis. Supposed mechanisms of action and the potential of clinical applications are also described.
引用
收藏
页码：1527 / 1542
页数：16
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