Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection

被引：24

作者：

Brumback, Brittany D. ^{[1
,2
]}

Dmytrenko, Oleksandr ^{[1
]}

Robinson, Ashley N. ^{[1
]}

Bailey, Adam L. ^{[3
,4
]}

Ma, Pan ^{[1
]}

Liu, Jing ^{[1
]}

Hicks, Stephanie C. ^{[1
]}

Ng, Sherwin ^{[1
]}

Li, Gang ^{[1
,2
]}

Zhang, David M. ^{[1
]}

Lipovsky, Catherine E. ^{[1
,5
]}

Lin, Chieh-Yu ^{[3
]}

Diamond, Michael S. ^{[3
,6
,7
]}

Lavine, Kory J. ^{[1
,3
,5
]}

Rentschler, Stacey L. ^{[1
,2
,5
,8
]}

机构：

[1] Washington Univ, Cardiovasc Div, Dept Med, St Louis, MO USA

[2] Washington Univ, Dept Biomed Engn, St Louis, MO USA

[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[4] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pathol & Lab Med, Madison, WI USA

[5] Washington Univ, Dept Dev Biol, St Louis, MO USA

[6] Washington Univ, Sch Med, Dept Med, Infect Dis, St Louis, MO USA

[7] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63130 USA

[8] Washington Univ, Sch Med, Dept Med, Cardiovasc Div, 309 McDonnell Sci Bldg, Campus POB 8103,660 South, St Louis, MO 63110 USA

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2023年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

cardiovascular disease; COVID-19; pericytes; SARS-CoV-2; ENDOTHELIAL DYSFUNCTION; COVID-19;

D O I：

10.1016/j.jacbts.2022.09.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

COVID-19 is associated with serious cardiovascular complications, with incompletely understood mechanism(s). Pericytes have key functions in supporting endothelial cells and maintaining vascular integrity. We demonstrate that human cardiac pericytes are permissive to SARS-CoV-2 infection in organotypic slice and primary cell cultures. Viral entry into pericytes is mediated by endosomal proteases, and infection leads to up-regulation of inflammatory markers, vasoactive mediators, and nuclear factor kappa-B-dependent cell death. Furthermore, we present evidence of cardiac pericyte infection in COVID-19 myocarditis patients. These data demonstrate that human cardiac pericytes are susceptible to SARS-CoV-2 infection and suggest a role for pericyte infection in COVID-19.

引用

页码：109 / 120

页数：12

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