C5 cleavage inhibition combined with C3 convertase targeting protects from disease development in a preclinical model of autoimmune skin disease

被引:0
|
作者
Laffer, Bjoern [1 ]
Kenno, Samyr [1 ]
Tsui, Ping [2 ]
Lee, Richard [2 ]
Weng, Christina [2 ]
Ehlers-Jeske, Elvira [1 ]
Song, Wenru [2 ]
Song, Wen-Chao [3 ]
Koehl, Joerg [1 ,4 ]
机构
[1] Univ Lubeck, Inst Syst Inflammat Res, Lubeck, Germany
[2] Kira Pharmaceut, Cambridge, MA USA
[3] Univ Penn, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA USA
[4] Cincinnati Childrens Hosp Med Ctr, Div Immunobiol, Cincinnati, OH USA
关键词
D O I
10.1016/j.imbio.2023.152487
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
33
引用
收藏
页码:11 / 12
页数:2
相关论文
共 28 条
  • [1] INHIBITION OF THE ALTERNATIVE C3 CONVERTASE AND CLASSICAL C5 CONVERTASE OF COMPLEMENT BY GROUP-A STREPTOCOCCAL-M PROTEIN
    HONG, K
    KINOSHITA, T
    TAKEDA, J
    KOZONO, H
    PRAMOONJAGO, P
    KIM, YU
    INOUE, K
    INFECTION AND IMMUNITY, 1990, 58 (08) : 2535 - 2541
  • [2] Methionine modification impairs the C5-cleavage function of cobra venom factor-dependent C3/C5 convertase
    Fu, QL
    Mcphie, P
    Gowda, DC
    BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1998, 45 (01): : 133 - 144
  • [3] C3 independent C5 activation pathway in pathogenesis of pemphigoid disease
    Kamaguchi, M.
    Tofern, S.
    Freire, P.
    Schmidt-Jimenez, L. F.
    Bieber, K.
    Schmidt, E.
    Ludwig, R. J.
    Verschoor, A.
    Izumi, K.
    EXPERIMENTAL DERMATOLOGY, 2023, 32 (04) : E64 - E64
  • [4] Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models
    Zwarthoff, Seline A.
    Berends, Evelien T. M.
    Mol, Sanne
    Ruyken, Maartje
    Aerts, Piet C.
    Jozsi, Mihaly
    de Haas, Carla J. C.
    Rooijakkers, Suzan H. M.
    Gorham, Ronald D., Jr.
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [5] STUDIES ON C3 CONVERTASES - INHIBITION OF C5 CONVERTASE FORMATION BY PEPTIDES CONTAINING AROMATIC AMINO-ACIDS
    KOSSOROTOW, A
    OPITZ, W
    ETSCHENBERG, E
    HADDING, U
    BIOCHEMICAL JOURNAL, 1977, 167 (02) : 377 - 382
  • [7] C5 inhibition prevents renal failure in a mouse model of lethal C3 glomerulopathy
    Williams, Allison Lesher
    Gullipalli, Damodar
    Ueda, Yoshiyasu
    Sato, Sayaka
    Zhou, Lin
    Miwa, Takashi
    Tung, Kenneth S.
    Song, Wen-Chao
    KIDNEY INTERNATIONAL, 2017, 91 (06) : 1386 - 1397
  • [8] TREATMENT OF THE C3 GAIN-OF-FUNCTION MOUSE MODEL OF AHUS THROUGH INHIBITION OF C5a, PROPERDIN OR THE C3 CONVERTASE
    Smith-Jackson, Kate
    Pappworth, Isabel Y.
    Gibson, Beth G.
    Vyas, Falguni S.
    Harris, Claire L.
    Kavanagh, David
    Kim, SungKwon
    Hourcade, Dennis E.
    Pham, Christine T. N.
    Marchbank, Kevin J.
    MOLECULAR IMMUNOLOGY, 2019, 114 : 454 - 454
  • [9] CONTROL OF HUMAN CLASSICAL COMPLEMENT PATHWAY C-3 CONVERTASE - INHIBITION OF C-3 CLEAVAGE BY C5 OR CELL-BOUND C3B
    STRUNK, RC
    GICLAS, PC
    FEDERATION PROCEEDINGS, 1979, 38 (03) : 1011 - 1011
  • [10] METABOLISM OF 5TH COMPONENT OF COMPLEMENT (C5) IN DISEASE AND ITS RELATIONSHIP TO C3 METABOLISM
    SISSONS, JGP
    LIEBOWITCH, J
    PETERS, DK
    CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1976, 51 (03): : P22 - P23