A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression

被引：2

作者：

Sharlo, Kristina A. ^{[1
]}

Lvova, Irina D. ^{[1
]}

Tyganov, Sergey A. ^{[1
]}

Sergeeva, Ksenia V. ^{[1
]}

Kalashnikov, Vitaly Y. ^{[1
]}

Kalashnikova, Ekaterina P. ^{[1
]}

Mirzoev, Timur M. ^{[1
]}

Kalamkarov, Grigoriy R. ^{[2
]}

Shevchenko, Tatiana F. ^{[2
]}

Shenkman, Boris S. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Biomed Problems, Myol Lab, Moscow 123007, Russia

[2] Russian Acad Sci, Emanuel Inst Biochem Phys, Moscow 119334, Russia

来源：

CURRENT ISSUES IN MOLECULAR BIOLOGY | 2023年 / 45卷 / 07期

基金：

俄罗斯科学基金会;

关键词：

hindlimb unloading; muscle activity; MyHC; MAP-kinase; soleus muscle; SKELETAL-MUSCLE; RAT SOLEUS; SPASTICITY; INCREASES; NFAT; JNK;

D O I：

10.3390/cimb45070354

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Skeletal muscle disuse leads to pathological muscle activity as well as to slow-to-fast fiber-type transformation. Fast-type fibers are more fatigable than slow-type, so this transformation leads to a decline in muscle function. Prochlorperazine injections previously were shown to attenuate autonomous rat soleus muscle electrical activity under unloading conditions. In this study, we found that prochlorperazine blocks slow-to-fast fiber-type transformation in disused skeletal muscles of rats, possibly through affecting calcium and ROS-related signaling.

引用

页码：5613 / 5630

页数：18

共 4 条

[1] HDAC4 Is Indispensable for Reduced Slow Myosin Expression at the Early Stage of Hindlimb Unloading in Rat Soleus Muscle
Paramonova, Inna I.
Vilchinskaya, Natalia A.
Shenkman, Boris S.
PHARMACEUTICALS, 2021, 14 (11)
[2] The Role of GSK-3β Phosphorylation in the Regulation of Slow Myosin Expression in Soleus Muscle during Functional Unloading
Sharlo, C. A.
Lomonosova, Y. N.
Turtikova, O. V.
Mitrofanova, O. V.
Kalamkarov, G. R.
Bugrova, A. E.
Shevchenko, T. F.
Shenkman, B. S.
BIOLOGICHESKIE MEMBRANY, 2017, 34 (06): : 164 - 171
[3] The Role of GSK-3β Phosphorylation in the Regulation of Slow Myosin Expression in Soleus Muscle during Functional Unloading
Sharlo C.A.
Lomonosova Y.N.
Turtikova O.V.
Mitrofanova O.V.
Kalamkarov G.R.
Bugrova A.E.
Shevchenko T.F.
Shenkman B.S.
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2018, 12 (1) : 85 - 91
[4] L-arginine supplementation attenuates capillary regression without increasing integrated succinate dehydrogenase activity and VEGF expression in skeletal muscle during hindlimb unloading
Uchida, Kensaku
Tanaka, Minoru
Kondo, Hiroyo
Ishihara, Akihiko
Fujino, Hidemi
GENERAL PHYSIOLOGY AND BIOPHYSICS, 2016, 35 (04) : 425 - 432

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