Akkermansia muciniphila alleviates high-fat-diet-related metabolic-associated fatty liver disease by modulating gut microbiota and bile acids

被引:18
|
作者
Wu, Wenrui [1 ]
Kaicen, Wang [1 ]
Bian, Xiaoyuan [1 ]
Yang, Liya [1 ]
Ding, Shi [1 ]
Li, Yating [1 ]
Li, Shengjie [1 ]
Zhuge, Aoxiang [1 ]
Li, Lanjuan [1 ,2 ,3 ]
机构
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis,Natl Cli, Hangzhou, Zhejiang, Peoples R China
[2] Jinan Microecol Biomed Shandong Lab, Jinan, Shandong, Peoples R China
[3] Zhejiang Univ, Sch Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis,Natl Cli, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China
来源
MICROBIAL BIOTECHNOLOGY | 2023年
基金
中国国家自然科学基金;
关键词
DYSBIOSIS; IMMUNITY; OBESITY;
D O I
10.1111/1751-7915.14293
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
It has been reported that Akkermansia muciniphila improves host metabolism and reduces inflammation; however, its potential effects on bile acid metabolism and metabolic patterns in metabolic-associated fatty liver disease (MAFLD) are unknown. In this study, we have analysed C57BL/6 mice under three feeding conditions: (i) a low-fat diet group (LP), (ii) a high-fat diet group (HP) and (iii) a high-fat diet group supplemented with A. muciniphila (HA). The results found that A. muciniphila administration relieved weight gain, hepatic steatosis and liver injury induced by the high-fat diet. A. muciniphila altered the gut microbiota with a decrease in Alistipes, Lactobacilli, Tyzzerella, Butyricimonas and Blautia, and an enrichment of Ruminiclostridium, Osclibacter, Allobaculum, Anaeroplasma and Rikenella. The gut microbiota changes correlated significantly with bile acids. Meanwhile, A. muciniphila also improved glucose tolerance, gut barriers and adipokines dysbiosis. Akkermansia muciniphila regulated the intestinal FXR-FGF15 axis and reshaped the construction of bile acids, with reduced secondary bile acids in the caecum and liver, including DCA and LCA. These findings provide new insights into the relationships between probiotics, microflora and metabolic disorders, highlighting the potential role of A. muciniphila in the management of MAFLD.
引用
收藏
页码:1924 / 1939
页数:16
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