Interleukin 1 beta and its association with the periodontal health of pregnant women

被引:1
作者
El Hassan, Nawal K. B. [1 ]
Ramadan, AbdelRahman M. [2 ,3 ]
机构
[1] El Razi Univ, Fac Dent Med & Surg, Dept Periodont, Khartoum, Sudan
[2] Ibn Sina Natl Coll Med Sci, Dept Oral & Basic Clin Sceinces, Jeddah, Saudi Arabia
[3] Ibn Sina Natl Coll, Dept Oral & Basic Clin Sci, Div Periodont, Al Mahjar St, Jeddah, Saudi Arabia
来源
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES | 2023年 / 18卷 / 06期
关键词
Interleukin-1; beta; Periodontal disease; Preg-nancy; Sudan; LOW-BIRTH-WEIGHT; GINGIVAL CREVICULAR FLUID; ORAL-HEALTH; DISEASE; CYTOKINES; OUTCOMES; RISK;
D O I
10.1016/j.jtumed.2023.05.012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: In this study, we measured and compared serum and gingival crevicular fluid (GCF) levels of interleukin 1 beta (IL-10) in pregnant women with peri-odontitis and pregnant women with a healthy perio-dontium. We also determined the prevalence of periodontitis among pregnant women attending Omdur-man Midwifery Hospital. Materials: This was a hospital-based clinical study and laboratory investigation using ELISA tests of 80 preg-nant women in the third trimester conducted at the Omdurman Midwifery Hospital in Khartoum, Sudan. The study group consisted of 50 women while the control group consisted of 30 women. Results: Independent samples t-tests were used to compare serum and GCF levels of IL-10 between the study and control groups. Pearson's correlation analysis was also used to compare gingival parameters and IL-10 levels in the GCF. For each comparison, the p-value was fixed at 0.05. The GCF in the research group showed a considerable increase in IL-10 levels. There was also a strong positive association between high IL-10 levels in the research group's GCF and probing pocket depth (PPD) and clinical attachment level (CAL) levels. Conclusions: Our study provides further evidence that periodontitis, as measured by a PD >4 mm and a CAL >3 mm, is associated with an increased level of IL-10 in the GCF of pregnant women with active periodontal disease during pregnancy and may include the transient translocation of oral organisms to the utero-placental unit, inciting placental inflammation or oxidative stress early in pregnancy, ultimately resulting in placental damage and clinical manifestations.
引用
收藏
页码:1376 / 1383
页数:8
相关论文
共 61 条
  • [1] Lack of association between maternal periodontal status and adverse pregnancy outcomes: a multicentric epidemiologic study
    Abati, Silvio
    Villa, Alessandro
    Cetin, Irene
    Dessole, Salvatore
    Luglie, Pietrina Francesca
    Strohmenger, Laura
    Ottolenghi, Livia
    Campus, Guglielmo G.
    [J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2013, 26 (04) : 369 - 372
  • [2] Anil S., 2015, Emerging Trends in Oral Health Sciences and Dentistry, P631, DOI [DOI 10.5772/59517, 10.5772/59517]
  • [3] Gingival Crevicular Fluid (GCF): A Diagnostic Tool for the Detection of Periodontal Health and Diseases
    Bibi, Tauqeer
    Khurshid, Zohaib
    Rehman, Ambreen
    Imran, Eisha
    Srivastava, Kumar Chandan
    Shrivastava, Deepti
    [J]. MOLECULES, 2021, 26 (05):
  • [4] Periodontal disease and adverse pregnancy outcomes
    Bobetsis, Yiorgos A.
    Graziani, Filippo
    Gursoy, Mervi
    Madianos, Phoebus N.
    [J]. PERIODONTOLOGY 2000, 2020, 83 (01) : 154 - 174
  • [5] Knowledge and beliefs regarding oral health among pregnant women
    Boggess, Kim A.
    Urlaub, Diana M.
    Moos, Merry-K
    Polinkovsky, Margaret
    El-Khorazaty, Jill
    Lorenz, Carol
    [J]. JOURNAL OF THE AMERICAN DENTAL ASSOCIATION, 2011, 142 (11) : 1275 - 1282
  • [6] Association between periodontal pathogens and systemic disease
    Bui, Fiona Q.
    Coutinho Almeida-da-Silva, Cassio Luiz
    Huynh, Brandon
    Trinh, Alston
    Liu, Jessica
    Woodward, Jacob
    Asadi, Homer
    Ojcius, David M.
    [J]. BIOMEDICAL JOURNAL, 2019, 42 (01) : 27 - 35
  • [7] Canakci V, 2007, J CLIN PERIODONTOL, V34, P639, DOI 10.1111/j.1600-051X.2007.01105.x
  • [8] Effect of intra-pregnancy nonsurgical periodontal therapy on inflammatory biomarkers and adverse pregnancy outcomes: a systematic review with meta-analysis
    Cardoso da Silva, Helbert Eustaquio
    Stefani, Cristine Miron
    Melo, Nilce de Santos
    de Lima, Adriano de Almeida
    Rosing, Cassiano Kuchenbecker
    Porporatti, Andre Luis
    Canto, Graziela De Luca
    [J]. SYSTEMATIC REVIEWS, 2017, 6
  • [9] Inflammatory and immune pathways in the pathogenesis of periodontal disease
    Cekici, Ali
    Kantarci, Alpdogan
    Hasturk, Hatice
    Van Dyke, Thomas E.
    [J]. PERIODONTOLOGY 2000, 2014, 64 (01) : 57 - 80
  • [10] Daalderop L A, 2018, JDR Clin Trans Res, V3, P10, DOI 10.1177/2380084417731097