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Metabolomics reveals the role of Lactobacillus plantarum SHY130 in hepatic metabolic regulation in a mouse model of type 2 diabetes
被引：1
|作者：
Wang, Guangqi
[2
,3
]
Song, Jiajia
[2
,3
]
Wang, Chen
[2
,3
]
Chen, Xiaoyong
[2
,3
]
Suo, Huayi
[1
,2
,3
,4
]
机构：
[1] Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China
[2] Southwest Univ, Coll Food Sci, Chongqing, Peoples R China
[3] Southwest Univ, Chongqing Agr Prod Proc Technol Innovat Platform, Chongqing, Peoples R China
[4] Southwest Univ, Natl Citrus Engn Res Ctr, Chongqing, Peoples R China
关键词：
type;
2;
diabetes;
probiotics;
liver injury;
hepatic metabolism;
metabolomics;
LIVER;
DISEASE;
MELLITUS;
MARKERS;
PURINE;
DAMAGE;
ACID;
D O I：
10.1002/jsfa.12716
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
BACKGROUNDAmong type 2 diabetes (T2D) patients, the incidence rate of liver metabolic disorders is much higher than that in healthy subjects. It was observed in our previous research that diabetic symptoms were improved by Lactobacillus plantarum SHY130 (LPSHY130) isolated from yak yogurt in a murine model of T2D. This study sought to investigate the LPSHY130-mediated hepatic metabolic regulation in a murine model of T2D. RESULTSTreatment with LPSHY130 improved liver function and pathological damage in diabetic mice. Untargeted metabolome analysis revealed that T2D-induced changes in 11 metabolites were regulated after LPSHY130 treatment, mainly involving purine metabolism, amino acid metabolism, and choline metabolism and pantothenate and coenzyme A biosynthesis pathways. In addition, correlation analysis indicated that hepatic metabolic changes can be adjusted by the intestinal microbiota. CONCLUSIONOverall, this study suggests that treatment with LPSHY130 relieves liver injury and regulates liver metabolism in a murine model of T2D, thus providing a theoretical basis for the use of probiotics as dietary supplements to regulate hepatic metabolic disorders associated with T2D. (c) 2023 Society of Chemical Industry.
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页码：6406 / 6415
页数：10
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