Metabolomic Profiles of Nonobese and Obese Women With Gestational Diabetes

被引：6

作者：

Sormunen-Harju, Heidi ^{[1
,2
,19
,20
]}

Huvinen, Emilia ^{[1
,2
]}

Girchenko, Polina, V ^{[3
]}

Kajantie, Eero ^{[4
,5
,6
,7
,8
,9
]}

Villa, Pia M. ^{[1
,2
]}

Hamalainen, Esa K. ^{[10
]}

Lahti-Pulkkinen, Marius ^{[3
,11
,12
]}

Laivuori, Hannele ^{[2
,13
,14
,15
,16
]}

Raikkonen, Katri ^{[3
]}

Koivusalo, Saila B. ^{[1
,2
,17
,18
]}

机构：

[1] Helsinki Univ Hosp, Dept Obstet & Gynecol, FI-00270 Helsinki, Finland

[2] Univ Helsinki, FI-00270 Helsinki, Finland

[3] Univ Helsinki, Fac Med, Dept Psychol & Logoped, FI-00270 Helsinki, Finland

[4] Oulu Univ Hosp, Clin Med Res Unit, MRC Oulu, FI-90220 Oulu, Finland

[5] Univ Oulu, FI-90220 Oulu, Finland

[6] Finnish Inst Hlth & Welf, Populat Hlth Unit, FI-00300 Helsinki, Finland

[7] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, NO-7491 Trondheim, Norway

[8] Helsinki Univ Hosp, Childrens Hosp, FI-00290 Helsinki, Finland

[9] Univ Helsinki, FI-00290 Helsinki, Finland

[10] Univ Eastern Finland, Dept Clin Chem, FI-70211 Kuopio, Finland

[11] Finnish Natl Inst Hlth & Welf, FI-00300 Helsinki, Finland

[12] Univ Edinburgh, Edinburgh EH8 9YL, Scotland

[13] Helsinki Univ Hosp, Med & Clin Genet, FI-00270 Helsinki, Finland

[14] Univ Helsinki, Inst Mol Med Finland, Helsinki Inst Life Sci, FI-00270 Helsinki, Finland

[15] Tampere Univ Hosp, Dept Obstet & Gynecol, FI-33520 Tampere, Finland

[16] Tampere Univ, Ctr Child Adolescent & Maternal Hlth Res, Fac Med & Hlth Technol, FI-33520 Tampere, Finland

[17] Turku Univ Hosp, Dept Obstet & Gynaecol, FI-20520 Turku, Finland

[18] Univ Turku, FI-20520 Turku, Finland

[19] Helsinki Univ Hosp, Dept Obstet & Gynecol, Biomedicum 2C,PL 705, Helsinki 00029, Finland

[20] Univ Helsinki, Biomedicum 2C,PL 705, Helsinki 00029, Finland

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2023年 / 108卷 / 11期

基金：

芬兰科学院;

关键词：

gestational diabetes; metabolomics; obesity; INSULIN-RESISTANCE; BIRTH-WEIGHT; PREGNANCY; MELLITUS; HETEROGENEITY; ASSOCIATION; OVERWEIGHT; SUBGROUPS; RISK;

D O I：

10.1210/clinem/dgad288

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context In non-pregnant population, nonobese individuals with obesity-related metabolome have increased risk for type 2 diabetes and cardiovascular diseases. The risk of these diseases is also increased after gestational diabetes. Objective This work aimed to examine whether nonobese (body mass index [BMI] < 30) and obese (BMI >= 30) women with gestational diabetes mellitus (GDM) and obese non-GDM women differ in metabolomic profiles from nonobese non-GDM controls. Methods Levels of 66 metabolic measures were assessed in early (median 13, IQR 12.4-13.7 gestation weeks), and across early, mid (20, 19.3-23.0), and late (28, 27.0-35.0) pregnancy blood samples in 755 pregnant women from the PREDO and RADIEL studies. The independent replication cohort comprised 490 pregnant women. Results Nonobese and obese GDM, and obese non-GDM women differed similarly from the controls across early, mid, and late pregnancy in 13 measures, including very low-density lipoprotein-related measures, and fatty acids. In 6 measures, including fatty acid (FA) ratios, glycolysis-related measures, valine, and 3-hydroxybutyrate, the differences between obese GDM women and controls were more pronounced than the differences between nonobese GDM or obese non-GDM women and controls. In 16 measures, including HDL-related measures, FA ratios, amino acids, and inflammation, differences between obese GDM or obese non-GDM women and controls were more pronounced than the differences between nonobese GDM women and controls. Most differences were evident in early pregnancy, and in the replication cohort were more often in the same direction than would be expected by chance alone. Conclusion Differences between nonobese and obese GDM, or obese non-GDM women and controls in metabolomic profiles may allow detection of high-risk women for timely targeted preventive interventions.

引用

页码：2862 / 2870

页数：9