Platinum-Nickel Nanoparticles with Enhanced Oxidase-like Activity for Total Antioxidant Capacity Bioassay

被引:54
作者
Wang, Xiaoyu [1 ,2 ]
Wei, Gen [2 ]
Liu, Wanling [2 ]
Zhang, Yihong [2 ]
Zhu, Chenxin [2 ]
Sun, Qi [2 ]
Zhang, Minxuan [2 ]
Wei, Hui [2 ,3 ]
机构
[1] Nanjing Forestry Univ, Coll Sci, Dept Chem & Mat Sci, Nanjing 210037, Jiangsu, Peoples R China
[2] Nanjing Univ, Coll Engn & Appl Sci, Nanjing Natl Lab Microstruct, Jiangsu Key Lab Artificial Funct Mat, Nanjing 210023, Jiangsu, Peoples R China
[3] Nanjing Univ, Sch Chem & Chem Engn, Chem & Biomed Innovat Ctr ChemBIC, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
NANOCERIA; PALLADIUM; NANOZYMES; ENZYME; SILVER; GOLD;
D O I
10.1021/acs.analchem.2c05425
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
While great progress in nanozyme-enabled analytical chemistry has been made, most current nanozyme-based biosensing platforms are based on peroxidase-like nanozymes. However, peroxidase-like nanozymes with multienzymatic activities can influence the detection sensitivity and accuracy, while the use of unstable hydrogen peroxide (H2O2) in a peroxidase-like catalytic reaction may result in the reproducibility challenge of sensing signals. We envision that constructing biosensing systems by using oxidase-like nanozymes can address these limitations. Herein, we reported that platinum-nickel nanoparticles (Pt-Ni NPs) with Pt-rich shells and Ni-rich cores possessed high oxidase-like catalytic efficiency, exhibiting a 2.18-fold higher maximal reaction velocity (v(max)) than initial pure Pt NPs. The oxidase-like Pt-Ni NPs were applied to develop a colorimetric assay for the determination of total antioxidant capacity (TAC). The antioxidant levels of four bioactive small molecules, two antioxidant nanomaterials, and three cells were successfully measured. Our work not only provides new insights for preparing highly active oxidase-like nanozymes but also manifests their applications for TAC analysis.
引用
收藏
页码:5937 / 5945
页数:9
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