Studies Towards The Synthesis of Tartrolons D and E

被引：0
作者：
Sunnapu, Ranganayakulu [1 ]
Rehman, Mintu [1 ]
Nanoth, Sreya [1 ]
Rajendar, Goreti [1 ]
机构：
[1] Indian Inst Sci Educ & Res Thiruvananthapuram, Sch Chem, Trivandrum 695551, Kerala, India
来源：
SYNTHESIS-STUTTGART | 2023年 / 55卷 / 14期
关键词：
macrodiolides; tartrolons; C3-C22; fragment; 1.5-asymmetric aldol; Sonogashira coupling; ANTIBIOTIC MACRODIOLIDE TARTROLON; STEREOSELECTIVE TOTAL-SYNTHESIS; MEDIATED ALDOL REACTIONS; RING-CLOSING METATHESIS; 1,5-ASYMMETRIC INDUCTION; GLIDING BACTERIA; ACID; BIOSYNTHESIS; DERIVATIVES; COMPOUND;
D O I：
10.1055/a-2048-2662
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise and stereoselective synthesis of a key fragment C3-C22 unit of tartrolons D and E is demonstrated. Three crucial fragments are combined to form the 20-carbon chain, which contains four stereogenic centers in the monomeric unit of both natural products. The crucial fragments were synthesized in highly enantioselective routes from commercial starting compounds in two, eight, and two steps, respectively, and coupled using palladium-catalyzed Sonogashira coupling and directed 1,5-asymmetric aldol reaction as key steps.
引用
收藏
页码：2134 / 2142
页数：9
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