Antioxidants: an approach for restricting oxidative stress induced neurodegeneration in Alzheimer's disease

被引：20

作者：

Dubey, Sonal ^{[1
]}

Singh, Ekta ^{[2
]}

机构：

[1] Dayananda Sagar Univ, Coll Pharmaceut Sci, Dept Pharmaceut Chem, Bengaluru 560078, Karnataka, India

[2] Acharya & BM Reddy Coll Pharm, Bengaluru 560107, Karnataka, India

来源：

INFLAMMOPHARMACOLOGY | 2023年 / 31卷 / 02期

关键词：

Alzheimer's disease; Antioxidant; Neurodegeneration; Oxidative stress; TRANSGENIC MOUSE MODEL; BETA-AMYLOID PEPTIDE; LIPID-PEROXIDATION; DOUBLE-BLIND; MITOCHONDRIAL-FUNCTION; COGNITIVE IMPAIRMENT; MEMORY IMPAIRMENT; APOLIPOPROTEIN-E; INDUCED TOXICITY; ASCORBIC-ACID;

D O I：

10.1007/s10787-023-01173-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alzheimer's disease (AD) is the leading cause of dementia, affecting millions of people worldwide. Oxidative stress contributes towards induction of neurodegeneration. It is one of the reasons behind initiation and progression of Alzheimer's disease. Understanding of oxidative balance and restoration of oxidative stress has demonstrated its effectiveness in the management of AD. Various natural and synthetic molecules have been found to be effective in different models of AD. Some clinical studies also support the use of antioxidants for prevention of neurodegeneration in AD. In this review we are summarizing the development of antioxidants to restrict oxidative stress induced neurodegeneration in AD.

引用

页码：717 / 730

页数：14

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