HIGH-INTENSITY FOCUSED ULTRASOUND FOR PATIENTS WITH CERVICAL INTRAEPITHELIAL NEOPLASIA 2/3: A PROSPECTIVE ONE-ARM STUDY

被引：8

作者：

Liu, Yujuan ^{[1
,2
]}

Wang, Wenping ^{[1
,2
]}

Hang, Miao ^{[1
]}

Qu, Dacheng ^{[1
,2
,3
]}

DUu, Chengchao ^{[1
,2
]}

Chen, Yan ^{[1
,2
]}

Reng, Jiaojiao ^{[1
]}

Chen, Liming ^{[1
]}

Liu, Shengfeng ^{[1
]}

Yang, Yamei ^{[1
]}

Zhou, Honggui ^{[1
,2
]}

机构：

[1] North Sichuan Med Coll, Dept Obstet & Gynecol, Affiliated Hosp, Nanchong, Peoples R China

[2] North Sichuan Med Coll, Noninvas & Microinvas Lab Gynecol, Affiliated Hosp, Nanchong, Peoples R China

[3] North Sichuan Med Coll, Dept Obstet & Gynecol, Affiliated Hosp, 01 Maoyuan Rd, Nanchong 637000, Peoples R China

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2023年 / 49卷 / 01期

关键词：

Cervical intraepithelial neoplasia; High-grade CIN; High-intensity focused ultrasound; therapy; REBACIN; HUMAN-PAPILLOMAVIRUS; MANAGEMENT; THERAPY;

D O I：

10.1016/j.ultrasmedbio.2022.09.020

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

The aim of this study was to ascertain the safety of high-intensity focused ultrasound (HIFU) for high-grade cervical intraepithelial neoplasia grade 2/3 (CIN 2/3) in patients with fertility requirements. This was a prospective one-arm study. Consecutive CIN 2/3 patients diagnosed with histopathology were screened, enrolled and treated from September 2019 to September 2020 in the Affiliated Hospital of North Sichuan Medical College. All patients were treated with a combination of HIFU and antiviral treatment with REBACIN. The scheduled fol-low-up visits were 1 week, 1 mo, 3 mo, 6 mo and 12 mo after surgery. The primary outcomes included cure and human papillomavirus clearance rates. We screened 287 consecutive CIN 2/3 patients in our hospital, 29 of whom were enrolled and treated in this study. The cure rate reached 82.8% at 7 mo after treatment and 96.6% within 1 y. The HPV-negative rate reached 72.4% (21/29) around 6 mo after treatment, with mild side effects during and after the procedure. Our study suggests that in CIN 2/3 study participants with fertility requirements, HIFU + REBACIN therapy is a safe and effective therapeutic option with a high cure rate, HPV clearance and few side effects. (c) 2022 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

引用

页码：375 / 379

页数：5

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