Biomarker S100B in plasma a screening tool for mild traumatic brain injury in an emergency department

被引：10

作者：

Hopman, Joella H. ^{[1
,5
]}

Santing, Juliette A. L. ^{[2
]}

Foks, Kelly A. ^{[3
]}

Verheul, Rolf J. ^{[4
]}

van der Linden, Christien M. ^{[1
]}

van den Brand, Crispijn L. ^{[1
]}

Jellema, Korne ^{[2
]}

机构：

[1] Haaglanden Med Ctr, Dept Emergency Med, The Hague, Netherlands

[2] Haaglanden Med Ctr, Dept Neurol, The Hague, Netherlands

[3] Erasmus MC, Dept Neurol, Rotterdam, Netherlands

[4] Haaglanden Med Ctr, Dept Clin Chem & Lab Med, The Hague, Netherlands

[5] Haaglanden Med Ctr, POB 432, NL-2501 CK The Hague, Netherlands

来源：

BRAIN INJURY | 2023年 / 37卷 / 01期

关键词：

Mild traumatic brain injury; S100B; emergency department; screening tool; head CT; MINOR HEAD-INJURY; COMPUTED-TOMOGRAPHY FINDINGS; PROTEIN; MANAGEMENT; DAMAGE; AGE;

D O I：

10.1080/02699052.2022.2145360

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IntroductionA computerized tomography (CT) scan is an effective test for detecting traumatic intracranial findings after mild traumatic brain injury (mTBI). However, a head CT is costly, and can only be performed in a hospital.ObjectiveTo determine if the addition of plasma S100B to clinical guidelines could lead to a more selective scanning strategy without compromising safety.MethodsWe conducted a single center prospective cohort study at the emergency department. Patients (>= 16 years) who received head CT and had a blood draw were included. The primary outcome was the accuracy of plasma S100B to predict the presence of any traumatic intracranial lesion on head CT.ResultsWe included 495 patients, out of the 74 patients who had traumatic intracranial lesions, 5 patients had a plasma S100B level below the cutoff value of 0.105 ug/L. For the detection of traumatic intracranial injury, S100B had a sensitivity of 0.932 , a specificity of 0.157, a negative predictive value of 0.930, and a positive predictive value of 0.163.ConclusionsAmong patients undergoing guideline-based CT scan for mTBI, the use of S100B, would results in a further decrease (14.8%) of CT scans but at a cost of missed injury, without clinical consequence, on CT.

引用

页码：47 / 53

页数：7