Artificial intelligence based detection of age-related macular degeneration using optical coherence tomography with unique image preprocessing

Purpose The aim of the study is to improve the accuracy of age related macular degeneration (AMD) disease in its earlier phases with proposed Capsule Network (CapsNet) architecture trained on speckle noise reduced spectral domain optical coherence tomography (SD-OCT) images based on an optimized Bayesian non-local mean (OBNLM) filter augmentation techniques. Methods A total of 726 local SD-OCT images were collected and labelled as 159 drusen, 145 dry AMD, 156 wet AMD and 266 normal. Region of interest (ROI) was identified. Speckle noise in SD-OCT images were reduced based on OBNLM filter. The processed images were fed to proposed CapsNet architecture to clasify SD-OCT images. Accuracy rates were calculated in both public and local dataset. Results Accuracy rate of local SD-OCT image dataset classification was achieved to a value of 96.39% after performing data augmentation and speckle noise reduction with OBNLM. The performance of proposed CapsNet was also evaluated on the public Kaggle dataset under the same processing procedures and the accuracy rate was calculated as 98.07%. The sensitivity and specificity rates were 96.72% and 99.98%, respectively. Conclusions The classification success of proposed CapsNet may be improved with robust pre-processing steps like; determination of ROI and denoised SD-OCT images based on OBNLM. These impactful image preprocessing steps yielded higher accuracy rates for determining different types of AMD including its precursor lesion on the both local and public dataset with proposed CapsNet architecture.