Research Progress on the Antioxidant Activity of Natural Diarylheptanoids: Mechanisms and Structure-activity Relationships

被引：1

作者：

Ma, An-Na ^{[1
]}

Yao, Tie ^{[3
]}

Guo, Ya-Jing ^{[1
]}

Zhao, Chong-Yan ^{[1
]}

Wang, Bing-jie ^{[1
]}

Li, Gen ^{[1
,2
]}

Qiu, Feng ^{[1
,2
,3
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China

[2] Tianjin Key Lab Therapeut Subst Tradit Chinese Med, Tianjin 301617, Peoples R China

[3] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Component based Tradit Chine, Tianjin 301617, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2024年

基金：

中国国家自然科学基金;

关键词：

Diarylheptanoids; curcumin; antioxidant; antioxidant mechanism; structure-effect relationship; plant metabolites; RADICAL SCAVENGING ACTIVITIES; OXIDATIVE STRESS; CORYLUS-AVELLANA; NITRIC-OXIDE; IN-VITRO; PHENOLIC-COMPOUNDS; HEME OXYGENASE-1; CYCLIZED DIARYLHEPTANOIDS; NITROGEN-DIOXIDE; MYRICA-RUBRA;

D O I：

10.2174/0109298673282309231226111037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antioxidant research has recently become a popular topic. Medicinal plants are important sources of novel active compounds. Diarylheptanoids, a typical family of secondary plant metabolites, are of great interest owing to their extensive spectrum of biological activities. They possess a unique 1,7-diphenylmethane structural skeleton. Thus, this review summarizes the natural linear or macrocyclic diarylheptanoids with antioxidant activity in the last two decades. In addition, the relationships between the structural characteristics of natural diarylheptanoids and their antioxidant capacity were also discussed. All the available data highlight the potential of natural diarylheptanoids as novel antioxidants.

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页数：30

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