Remnant cholesterol and low-grade inflammation jointly in atherosclerotic cardiovascular disease: implications for clinical trials

被引:12
作者
Elias-Lopez, Daniel [1 ,2 ,3 ]
Doi, Takahito [1 ,2 ]
Nordestgaard, Borge G. [1 ,2 ,4 ]
Kobylecki, Camilla J. [1 ,2 ,5 ]
机构
[1] Copenhagen Univ Hosp Herlev Gentofte, Dept Clin Biochem, Herlev, Denmark
[2] Copenhagen Univ Hosp Herlev Gentofte, Copenhagen Gen Populat Study, Herlev, Denmark
[3] Natl Inst Med Sci & Nutr Salvador Zubiran, Res Ctr Metab Dis, Dept Endocrinol & Metab, Mexico City, Mexico
[4] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
[5] Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Denmark
关键词
C-reactive protein; low-density lipoprotein cholesterol; triglyceride-rich lipoproteins; triglycerides; very low-density lipoprotein; C-REACTIVE PROTEIN; TRIGLYCERIDE-RICH LIPOPROTEINS; CORONARY ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION; RISK; ASSOCIATION; INSIGHTS; GUIDELINES; OUTCOMES; EVENTS;
D O I
10.1097/MCO.0000000000000999
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of reviewAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of death despite the development of effective treatments. Recently, elevated remnant cholesterol and low-grade inflammation have emerged as factors explaining part of the residual ASCVD risk. Interestingly, the coexistence of both high remnant cholesterol and low-grade inflammation can further increase the risk of ASCVD. The aim of this review is to describe the role of elevated remnant cholesterol and low-grade inflammation, separately and combined, in ASCVD.Recent findingsResults from recently published studies, including observational and genetic Mendelian randomization studies, support a causal relationship between elevated remnant cholesterol and low-grade inflammation on risk of ASCVD in both primary and secondary prevention settings. In addition, current evidence from observational studies suggests that the coexistence of elevated remnant cholesterol and low-grade inflammation further increases the risk of ASCVD.SummaryRecent observational studies suggest that high remnant cholesterol combined with low-grade inflammation may confer a particular high risk for ASCVD. Attention on the dual threat from high remnant cholesterol and low-grade inflammation is necessary, and further research in this field is warranted. The effect of remnant cholesterol-lowering drugs and anti-inflammatory drugs on ASCVD risk alone and combined remains to be elucidated.Video abstracthttp://links.lww.com/COCN/A20
引用
收藏
页码:125 / 135
页数:11
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