Effect of donor-recipient size mismatch on long-term graft survival in pediatric kidney transplantation: a multicenter cohort study

被引：0

作者：

Park, Min Ji

Baek, Hee Sun ^{[1
]}

Song, Ji Yeon ^{[2
]}

Choi, Naye ^{[3
]}

Ahn, Yo Han ^{[3
,4
]}

Kang, Hee Gyung ^{[3
,4
]}

Cho, Min Hyun ^{[5
,6
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea

[2] Yeungnam Univ, Coll Med, Dept Pediat, Daegu, South Korea

[3] Pusan Natl Univ, Sch Med, Pusan Natl Univ Childrens Hosp, Dept Pediat, Yangsan, South Korea

[4] Seoul Natl Univ, Coll Med, Dept Pediat, Seoul Natl Univ Childrens Hosp, Seoul, South Korea

[5] Seoul Natl Univ, Med Res Ctr, Kidney Res Inst, Seoul, South Korea

[6] Kyungpook Natl Univ Hosp, Dept Pediat, 130 Dongdeok Ro, Daegu 41944, South Korea

来源：

KIDNEY RESEARCH AND CLINICAL PRACTICE | 2023年 / 42卷 / 06期

关键词：

Donor; Kidney transplantation; Pediatrics; Recipient; RENAL-TRANSPLANTATION; KOREAN CHILDREN; OUTCOMES; WEIGHT; INFANTS; GROWTH; LENGTH; VOLUME;

D O I：

10.23876/j.krcp.23.170

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Donor-recipient size mismatching is commonly occurs in pediatric kidney transplantation (KT). However, its effect on graft survival remains unknown. This study aimed to determine the effect of donor-recipient size mismatch on the long-term survival rate of transplant kidneys in pediatric KT. Methods: A total of 241 pediatric patients who received KT were enrolled. The medical records of all patients were retrospectively re-viewed, and the correlation between donor-recipient size mismatch and graft function and long-term graft outcome was analyzed ac-cording to donor-recipient size mismatch. Results: Recipients and donors' mean body weight at the time of KT were 34.31 +/- 16.85 and 56.53 +/- 16.73 kg, respectively. The mean follow-up duration was 96.49 +/- 52.98 months. A significant positive correlation was observed between donor-recipient body weight ratio (DRBWR) or donor-recipient body surface area ratio (DRBSR) and graft function until 1 year after KT. However, this cor-relation could not be confirmed at the last follow-up. The results of long-term survival analysis using Fine and Gray's subdistribution hazard model showed no significant difference of the survival rate of the transplant kidney according to DRBWR or DRBSR. Conclusion: Donor-recipient size mismatch in pediatric KT is not an important factor in determining the long-term prognosis of trans-plant kidneys.

引用

页码：731 / 741

页数：11