Congenital hypogonadotrophic hypogonadism, induction of minipuberty, and future fertility

被引:2
|
作者
Stuckey, Bronwyn G. A. [1 ,2 ,3 ]
Nolan, James D. [2 ]
Hurley, David M. [4 ]
Martin, Graeme B. [5 ]
机构
[1] Keogh Inst Med Res, Nedlands, WA, Australia
[2] Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Nedlands, WA, Australia
[3] Univ Western Australia, Sch Med, Nedlands, WA, Australia
[4] Royal Perth Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia
[5] Univ Western Australia, Sch Agr & Environm, Nedlands, WA, Australia
来源
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS | 2023年 / 2023卷 / 03期
基金
英国医学研究理事会;
关键词
Adult; Male; White; Australia; Testes; Puberty; Novel treatment; July; 2023;
D O I
10.1530/EDM-23-0038
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 33-year-old man with Kallmann syndrome had received pulsatile GnRH as an infant for the treatment of cryptorchidism. As an adult, his treatment for fertility with gonadotrophins was unusually rapid compared with expectations, with a total sperm count of 25 million after only 12 months of gonadotrophin therapy. We propose that pulsatile GnRH treatment as an infant induced minipuberty and facilitated his successful, rapid response to therapy. We also propose that identification of the absence of minipuberty in infants with clinical signs suggesting congenital hypogonadotrophic hypogonadism (CHH) is an opportunity for intervention with pulsatile GnRH yielding benefits for fertility decades later.
引用
收藏
页数:5
相关论文
共 50 条
  • [31] Adherence to treatment in men with hypogonadotrophic hypogonadism
    Dwyer, Andrew A.
    Tiemensma, Jitske
    Quinton, Richard
    Pitteloud, Nelly
    Morin, Diane
    CLINICAL ENDOCRINOLOGY, 2017, 86 (03) : 377 - 383
  • [32] Induction of spermatogenesis in isolated hypogonadotrophic hypogonadism with gonadotrophins and early intervention with intracytoplasmic sperm injection
    Yong, EL
    Lee, KO
    Ng, SC
    Ratnam, SS
    HUMAN REPRODUCTION, 1997, 12 (06) : 1230 - 1232
  • [33] SEX STEROID PRIMING FOR INDUCTION OF PUBERTY IN THALASSEMIA PATIENTS WITH PULSATILE REVERSIBLE HYPOGONADOTROPHIC HYPOGONADISM
    Chatterjee, Ratna
    Mukhopadhyay, Tarak Nath
    Chandra, Sharmila
    Bajoria, Rekha
    HEMOGLOBIN, 2011, 35 (5-6) : 659 - 664
  • [34] Functional characterization of a new homozygous mutation of kisspeptin receptor in a familial case of congenital hypogonadotrophic hypogonadism
    Brioude, F.
    Bouligand, J.
    Brailly-Tabrd, S.
    Lombes, M.
    Young, J.
    Guiochon-Mantel, A.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2010, 24 : 4 - 4
  • [35] Minipuberty - Looking into the future
    Main, Katharina M.
    HORMONE RESEARCH IN PAEDIATRICS, 2023, 96 : 18 - 18
  • [36] GnRH neuronal development: insights into hypogonadotrophic hypogonadism
    MacColl, G
    Quinton, R
    Bouloux, PMG
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (03): : 112 - 118
  • [37] A novel mouse model of hypogonadotrophic hypogonadism.
    Pask, AJ
    Kanasaki, H
    Kaiser, UB
    Justice, MJ
    Behringer, RB
    DEVELOPMENTAL BIOLOGY, 2004, 271 (02) : 592 - 593
  • [38] Taste and olfactory functions in hypogonadotrophic hypogonadism patients
    Salihoglu, Murat
    Deniz, Ferhat
    Kurt, Onuralp
    Ay, Seyid Ahmet
    Altundag, Aytug
    Baskoy, Kamil
    Tekeli, Hakan
    Saglam, Muzaffer
    Yonem, Arif
    Hummel, Thomas
    CHEMICAL SENSES, 2016, 41 (09) : E163 - E164
  • [39] HYPOGONADOTROPHIC HYPOGONADISM IN LAURENCE-MOON SYNDROME
    REINFRANK, RF
    NICHOLS, FL
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1964, 24 (01): : 48 - +
  • [40] Ejaculatory failure and hypogonadotrophic hypogonadism caused by haemochromatosis
    Stopforth, HB
    Heyns, CF
    De Kock, MLS
    Sandler, M
    BJU INTERNATIONAL, 1999, 83 (06) : 728 - 728