Rhodium-Catalyzed C-H Activation of 2-Arylquinazolinones and Cyclization with Elemental Sulfur via C-S/S-N Bond Formation to Access 7 H -Benzo[4,5]isothiazolo[3,2-b ]quinazolinones

被引：1

作者：

Zhang, Xinqin ^{[1
]}

Wu, Qiong ^{[1
]}

Yang, Qin ^{[1
]}

Fu, Yang ^{[1
]}

Peng, Yiyuan ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Key Lab Green Chem Jiangxi Prov, 99 Ziyang Ave, Nanchang 330022, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2023年 / 55卷 / 20期

基金：

中国国家自然科学基金;

关键词：

C-H activation; quinazoline; heterocycle; sulfur; benzisothiazoloquinazolinone; NATURALLY-OCCURRING QUINAZOLINONE; QUINOLINE; CHEMISTRY;

D O I：

10.1055/a-2147-2620

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of 7H-benzo[4,5] isothiazolo[3,2-b]quinazolin-7-ones by the reaction of 2-arylquinazolin-4(3H)-ones and elemental sulfur is described. The rhodium-catalyzed C-H activation of 2-arylquinazolinones and cyclization with elemental sulfur via one-step formation of C-S/N-S bonds to give the corresponding 7H-benzo[4,5] isothiazolo[3,2-b]quinazolinones is realized in good to high yields with good functional group tolerance.

引用

页码：3364 / 3372

页数：9

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