Effects of BL 23 (Shenshu) acupuncture on serum cytokine levels in healthy adults: A randomized double-blind sham-controlled phase 1 study

被引：2

作者：

Murakami, Eiko ^{[1
]}

Uzawa, Akiyuki ^{[1
]}

Ozawa, Yoshihito ^{[2
]}

Yasuda, Manato ^{[1
]}

Onishi, Yosuke ^{[1
]}

Ozawa, Yukiko ^{[1
]}

Akamine, Hiroyuki ^{[1
]}

Kawamoto, Mariko ^{[1
]}

Shiko, Yuki ^{[2
]}

Kawasaki, Yohei ^{[3
]}

Kuwabara, Satoshi ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Neurol, 1-8-1 Inohana,Chuo Ku, Chiba, Chiba 2608670, Japan

[2] Chiba Univ Hosp, Clin Res Ctr, Chiba, Japan

[3] Japanese Red Cross Coll Nursing, Fac Nursing, Tokyo, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2023年 / 382卷

关键词：

Acupuncture; BL23; Clinical trial; Cytokine; TNF-& alpha; PAIN;

D O I：

10.1016/j.jneuroim.2023.578165

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The purpose of this study was to evaluate the safety and efficacy of BL 23 (Shenshu) acupuncture on serum cytokine levels. Sixteen healthy adults were randomized into the BL 23 acupuncture group or pseudoacupuncture group and changes of serum cytokines were analyzed. The changes in IL-13, TNF-a, and GM-CSF levels were different between the BL 23 acupuncture group and pseudo-acupuncture group (P < 0.05). No adverse events associated with acupuncture were observed. In conclusion, BL 23 acupuncture can suppress immune responses via decreases in TNF-a and suppression of increases in IL-13 and GM-CSF. This study elucidated some of the mechanisms of the acupuncture effect.

引用

页数：5

共 16 条

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