Signaling pathways of oxidative stress response: the potential therapeutic targets in gastric cancer

被引：29
作者：
Liu, Yingying [1 ,2 ,3 ,4 ]
Shi, Yu [5 ]
Han, Ruiqin [6 ]
Liu, Chaoge [7 ,8 ]
Qin, Xiaogang [9 ]
Li, Pengfei [10 ]
Gu, Renjun [1 ,2 ]
机构：
[1] Nanjing Univ Chinese Med, Sch Chinese Med, Nanjing, Peoples R China
[2] Nanjing Univ Chinese Med, Sch Integrated Chinese & Western Med, Nanjing, Peoples R China
[3] Tsinghua Univ, Inst Immunol, Beijing, Peoples R China
[4] Tsinghua Univ, Sch Med, Beijing, Peoples R China
[5] Tongji Univ, Shanghai East Hosp, Sch Med, Shanghai, Peoples R China
[6] Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Dept Biochem & Mol Biol, State Key Lab Med Mol Biol, Beijing, Peoples R China
[7] Nankai Univ, Tianjin Stomatol Hosp, Sch Med, Dept Oromaxillofacial Head & Neck Surg, Tianjin, Peoples R China
[8] Tianjin Key Lab Oral & Maxillofacial Funct Reconst, Tianjin, Peoples R China
[9] Tradit Chinese Med Hosp Tongzhou Dist, Nantong, Jiangsu, Peoples R China
[10] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Clin Lab, Nanjing, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
gastric cancer; oxidative stress; signaling pathways; pathophysiology; therapeutic targets; HELICOBACTER-PYLORI INFECTION; NITRO-N-NITROSOGUANIDINE; BONE MORPHOGENETIC PROTEIN-2; PLASMINOGEN-ACTIVATOR; S-ALLYLCYSTEINE; RISK-FACTORS; EXPRESSION; SUPPLEMENTATION; PROMOTES; EPIDEMIOLOGY;
D O I：
10.3389/fimmu.2023.1139589
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Gastric cancer is one of the top causes of cancer-related death globally. Although novel treatment strategies have been developed, attempts to eradicate gastric cancer have been proven insufficient. Oxidative stress is continually produced and continually present in the human body. Increasing evidences show that oxidative stress contributes significantly to the development of gastric cancer, either through initiation, promotion, and progression of cancer cells or causing cell death. As a result, the purpose of this article is to review the role of oxidative stress response and the subsequent signaling pathways as well as potential oxidative stress-related therapeutic targets in gastric cancer. Understanding the pathophysiology of gastric cancer and developing new therapies for gastric cancer depends on more researches focusing on the potential contributors to oxidative stress and gastric carcinogenesis.
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页数：12
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