Visible-light-enable d ruthenium-catalyze d para -C -H difluoroalkylation of anilides

被引：21

作者：

Cheng, Yaohang ^{[1
]}

Zhang, Xian ^{[1
]}

An, Guanghui ^{[1
]}

Li, Guangming ^{[1
]}

Yang, Zhenyu ^{[2
]}

机构：

[1] Heilongjiang Univ, Sch Chem & Mat Sci, Key Lab Funct Inorgan Mat Chem MOE, Harbin 150080, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut & Mat Engn, Taizhou 318000, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2023年 / 34卷 / 03期

关键词：

C -H activation; para; Selectivity; Photocatalysis; Difluoroalkylation; Late -stage functionalization; PARA-SELECTIVE ALKYLATION; ACTIVATION; META; DIFLUOROMETHYLATION; FUNCTIONALIZATION; BORYLATION; REGIOSELECTIVITY; AMINATION; ARYLATION; STRATEGY;

D O I：

10.1016/j.cclet.2022.06.048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Visible-light-mediated para -C-H difluoroalkylation of anilides via combination of steric effects and Lewis acid activation strategies has been developed. The addition of (C 6 H 5 O) 2 P(O)OH and Ag 2 CO 3 properly tune the redox potential of ruthenium catalyst and leads to mild reaction conditions. The protocol exhibits broad functional group tolerance and allows the late-stage functionalization of complex bioactive molecules. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

引用

页数：5

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