Disease-specific assessment of Vision Impairment in Low Luminance in age-related macular degeneration - a MACUSTAR study report

被引:5
作者
Terheyden, Jan Henrik [1 ]
Pondorfer, Susanne G. [1 ]
Behning, Charlotte [2 ]
Berger, Moritz [3 ]
Carlton, Jill [4 ]
Rowen, Donna [4 ]
Bouchet, Christine [5 ]
Poor, Stephen [5 ]
Luhmann, Ulrich F. O. [6 ]
Leal, Sergio [7 ]
Holz, Frank G. [1 ]
Butt, Thomas [8 ]
Brazier, John E. [4 ]
Finger, Robert P. [1 ]
机构
[1] Univ Hosp Bonn, Dept Ophthalmol, Bonn, Germany
[2] Univ Hosp Bonn, Dept Med Biometry Informat & Epidemiol, Bonn, Germany
[3] Univ Bonn, Dept Med Biometry Informat & Epidemiol, Bonn, Germany
[4] Univ Sheffield, Sch Hlth & Related Res, Sheffield, S Yorkshire, England
[5] Novartis Pharma AG, Basel, Switzerland
[6] Roche Innovat Ctr Basel, Roche Pharmaceut Res & Early Dev, Translat Med Ophthalmol, Basel, Switzerland
[7] Bayer AG, Berlin, Germany
[8] UCL, UCL Inst Ophthalmol, London, England
基金
欧盟地平线“2020”;
关键词
QUALITY-OF-LIFE; END-POINTS; TRANSLATION; QUESTIONNAIRE; RELIABILITY; VALIDATION; BIOMARKERS; DIF;
D O I
10.1136/bjophthalmol-2021-320848
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Background/aims To further validate the Vision Impairment in Low Luminance (VILL) questionnaire, which captures visual functioning and vision-related quality of life (VRQoL) under low luminance, low-contrast conditions relevant to age-related macular degeneration (AMD). Methods The VILL was translated from German into English (UK), Danish, Dutch, French, Italian and Portuguese. Rasch analysis was used to assess psychometric characteristics of 716 participants (65% female, mean age 72 +/- 7 years, 82% intermediate AMD) from the baseline visit of the MACUSTAR study. In a subset of participants (n=301), test-retest reliability (intraclass correlation coefficient (ICC) and coefficient of repeatability (CoR)) and construct validity were assessed. Results Four items were removed from the VILL with 37 items due to misfit. The resulting Vision Impairment in Low Luminance with 33 items (VILL-33) has three subscales with no disordered thresholds and no misfitting items. No differential item functioning and no multidimensionality were observed. Person reliability and person separation index were 0.91 and 3.27 for the Vision Impairment in Low Luminance Reading Subscale (VILL-R), 0.87 and 2.58 for the Vision Impairment in Low Luminance Mobility Subscale (VILL-M), and 0.78 and 1.90 for the Vision Impairment in Low Luminance Emotional Subscale (VILL-E). ICC and CoR were 0.92 and 1.9 for VILL-R, 0.93 and 1.8 for VILL-M and 0.82 and 5.0 for VILL-E. Reported VRQoL decreased with advanced AMD stage (p<0.0001) and was lower in the intermediate AMD group than in the no AMD group (p <= 0.0053). Conclusion The VILL is a psychometrically sound patient-reported outcome instrument, and the results further support its reliability and validity across all AMD stages. We recommend the shortened version of the questionnaire with three subscales (VILL-33) for future use.
引用
收藏
页码:1144 / 1150
页数:7
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