Ameliorative effect of vitamin E and selenium against bisphenol A-induced toxicity in spinal cord and submandibular salivary glands of adult male albino rats

被引：2
作者：
Bashir, Dina W. [1 ]
Ahmed, Yasmine H. [1 ]
El-Sakhawy, Mohamed A. [1 ]
机构：
[1] Cairo Univ, Fac Vet Med, Dept Cytol & Histol, Cairo, Egypt
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH | 2023年 / 33卷 / 10期
关键词：
Bisphenol a; vitamin E selenium; histopathology; oxidative stress; immunohistochemistry; FIBRILLARY ACIDIC PROTEIN; OXIDATIVE STRESS; CELL-DEATH; NONYLPHENOL; LIVER; EXPOSURE; DAMAGE; INJURY; BRAIN; OCTYLPHENOL;
D O I：
10.1080/09603123.2022.2067327
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Bisphenol A (BPA) used in plastic industry. This study evaluate ameliorative effect of vitamin E and selenium in combating BPA toxicity in spinal cord (SC) and submandibular glands (SMGs). Thirty rats divided into three groups [Group I, controls; Group II, BPA orally (25 mg/kg) three times a week, 60 days; Group III, BPA (25 mg/kg) plus vitamin E and selenium in water (1 ml/L/day)]. By histopathological, immunohistochemical, and biochemical investigations. Bisphenol A group showed degenerative alterations. SC gray matter showed pyknotic nuclei and white matter revealed neuropil degeneration. Myelinated fibers showed dispersed myelin. SMGs, exhibited vacuolated cytoplasm in acinar cells. Intense glial fibrillary acidic protein in SC and strong proliferating cell nuclear antigen in acinar and ductal cell nuclei of SMGs. Malondialdehyde elevated in SC and catalase decreased in SMG. Group III, SC and SMG revealed partial recovery. Vitamin E and selenium displayed protective effects against BPA toxicity in SC and SMGs.
引用
收藏
页码：993 / 1009
页数：17
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