An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo

被引:43
作者
Cho, Seonghee [1 ,2 ]
Kim, Minsu [2 ,3 ]
Ahn, Joongho [2 ,3 ]
Kim, Yeonggeun [2 ,3 ]
Lim, Junha [4 ]
Park, Jeongwoo [2 ,3 ]
Kim, Hyung Ham [1 ,2 ,3 ]
Kim, Won Jong [4 ,5 ]
Kim, Chulhong [1 ,2 ,3 ,5 ,6 ]
机构
[1] Pohang Univ Sci & Technol, Dept Elect Engn, Pohang, South Korea
[2] Pohang Univ Sci & Technol, Med Device Innovat Ctr, Pohang, South Korea
[3] Pohang Univ Sci & Technol, Dept Convergence IT Engn, Pohang, South Korea
[4] Pohang Univ Sci & Technol, Dept Chem, Pohang, South Korea
[5] Pohang Univ Sci & Technol, Dept Med Sci & Engn, Pohang, South Korea
[6] Pohang Univ Sci & Technol, Dept Mech Engn, Pohang, South Korea
基金
新加坡国家研究基金会;
关键词
DESIGN; MICROSCOPY; EFFICIENT;
D O I
10.1038/s41467-024-45273-4
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Transparent ultrasound transducers (TUTs) can seamlessly integrate optical and ultrasound components, but acoustic impedance mismatch prohibits existing TUTs from being practical substitutes for conventional opaque ultrasound transducers. Here, we propose a transparent adhesive based on a silicon dioxide-epoxy composite to fabricate matching and backing layers with acoustic impedances of 7.5 and 4-6 MRayl, respectively. By employing these layers, we develop an ultrasensitive, broadband TUT with 63% bandwidth at a single resonance frequency and high optical transparency ( > 80%), comparable to conventional opaque ultrasound transducers. Our TUT maximises both acoustic power and transfer efficiency with maximal spectrum flatness while minimising ringdowns. This enables high contrast and high-definition dual-modal ultrasound and photoacoustic imaging in live animals and humans. Both modalities reach an imaging depth of > 15 mm, with depth-to-resolution ratios exceeding 500 and 370, respectively. This development sets a new standard for TUTs, advancing the possibilities of sensor fusion.
引用
收藏
页数:15
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