Photodynamic Inactivation of Staphylococcus aureus Using Aloe-emodin as Photosensitizer

被引：8
|
作者：
Wu, Jiali [1 ,2 ]
Pang, Yaokun [1 ,2 ]
Liu, Dan [1 ,2 ,4 ]
Sun, Jianxia [1 ,2 ]
Bai, Weibin [3 ,5 ]
机构：
[1] Guangdong Univ Technol, Fac Chem Engn & Light Ind, Guangzhou 510006, Peoples R China
[2] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangdong Prov Key Lab Plant Resources Biorefinery, Guangzhou 510006, Guangdong, Peoples R China
[3] Jinan Univ, Inst Food Safety & Nutr, Guangdong Engn Technol Ctr Food Safety Mol Rapid D, Dept Food Sci & Engn, Guangzhou, Guangdong, Peoples R China
[4] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Dept Food Sci & Engn, Guangzhou 510006, Peoples R China
[5] Jinan Univ, Inst Food Safety & Nutr, Guangdong Engn Technol Ctr Food Safety Mol Rapid D, Dept Food Sci & Engn, Guangzhou 510632, Peoples R China
来源：
FOOD RESEARCH INTERNATIONAL | 2024年 / 178卷
基金：
中国国家自然科学基金;
关键词：
S; aureus; Aloe-emodin; Photodynamic inactivation; Singlet oxygen; Apple juice; THERAPY; MECHANISMS;
D O I：
10.1016/j.foodres.2024.113959
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Aloe-emodin (AE) is a natural compound with photodynamic properties. The aim of this study was to investigate the inhibitory effect of AE-mediated photodynamic inactivation (PDI) on Staphylococcus aureus (S. aureus). The bacteriostatic efficiency under different photodynamic conditions and photosensitizing mechanism was studied in detail. The results showed that AE-mediated PDI exhibited a typical concentration and time-dependent characteristics. In terms of bactericidal mechanism, disruption of membrane integrity and increase of cell membrane permeability was observed. Type II reaction was assumed as the main photochemical reaction involved in AE-mediated PDI as evidenced by the action of different ROS quenching agents. Furthermore, AEmediated PDI decreased the bacterial survival in freshly squeezed apple juice and maintained its quality. The combination of blue light and AE enlarged the application of AE as an effective natural photosensitizer suitable for a food system.
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页数：10
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