Viral oncogenes, viruses, and cancer: a third-generation sequencing perspective on viral integration into the human genome

被引:8
|
作者
Ye, Ruichen [1 ,2 ,3 ]
Wang, Angelina [4 ]
Bu, Brady [5 ]
Luo, Pengxiang [6 ]
Deng, Wenjun [7 ]
Zhang, Xinyi [8 ]
Yin, Shanye [1 ,2 ]
机构
[1] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA
[2] Einstein Pathol Single Cell & Bioinformat Lab, Bronx, NY 10461 USA
[3] SUNY Stony Brook, Stony Brook, NY USA
[4] Tufts Friedman Sch Nutr, Boston, MA USA
[5] Horace Mann Sch, Bronx, NY USA
[6] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan, Peoples R China
[7] Harvard Med Sch, Massachusetts Gen Hosp, Clin Prote Res Ctr, Boston, MA 02115 USA
[8] Nanchang Univ, Dept Resp Dis, Affiliated Hosp 2, Nanchang, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词
viral integration; cancer sequencing; third generation sequencing; nanopore; PacBio; STRUCTURAL VARIATION; SINGLE-MOLECULE; HEPATITIS-B; HPV STATUS; IMMUNOBIOLOGY; TECHNOLOGIES; TRANSCRIPTS;
D O I
10.3389/fonc.2023.1333812
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The link between viruses and cancer has intrigued scientists for decades. Certain viruses have been shown to be vital in the development of various cancers by integrating viral DNA into the host genome and activating viral oncogenes. These viruses include the Human Papillomavirus (HPV), Hepatitis B and C Viruses (HBV and HCV), Epstein-Barr Virus (EBV), and Human T-Cell Leukemia Virus (HTLV-1), which are all linked to the development of a myriad of human cancers. Third-generation sequencing technologies have revolutionized our ability to study viral integration events at unprecedented resolution in recent years. They offer long sequencing capabilities along with the ability to map viral integration sites, assess host gene expression, and track clonal evolution in cancer cells. Recently, researchers have been exploring the application of Oxford Nanopore Technologies (ONT) nanopore sequencing and Pacific BioSciences (PacBio) single-molecule real-time (SMRT) sequencing in cancer research. As viral integration is crucial to the development of cancer via viruses, third-generation sequencing would provide a novel approach to studying the relationship interlinking viral oncogenes, viruses, and cancer. This review article explores the molecular mechanisms underlying viral oncogenesis, the role of viruses in cancer development, and the impact of third-generation sequencing on our understanding of viral integration into the human genome.
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页数:7
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