The role of N6-methyladenosine RNA modification in platinum resistance

被引：0
作者：
Wang, Kai [1 ,2 ]
Wang, Lingfang [1 ]
Chen, Xiaojing [1 ]
Gu, Jiaxin [1 ]
Cheng, Xiaodong [1 ]
机构：
[1] Zhejiang Univ, Womens Hosp, Sch Med, Dept Gynecol Oncol, Hangzhou 310000, Peoples R China
[2] Wenzhou Med Univ, Dept Obstet & Gynecol, Taizhou Hosp Zhejiang Prov, Linhai 317000, Peoples R China
来源：
EPIGENOMICS | 2023年 / 15卷 / 22期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
cancer; m6A RNA modification; platinum resistance; prognostic outcomes; M(6)A METHYLATION; CANCER CELLS; CISPLATIN; DIFFERENTIATION; PROLIFERATION; TUMORIGENESIS; OXALIPLATIN; REGULATORS; LEUKEMIA;
D O I：
10.2217/epi-2023-0289
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
N-6-methyladenosine (m6A) RNA methylation, a dynamic regulator of transcript expression, plays a pivotal role in cancer by influencing diverse mRNA processes, including nuclear export, splicing, translation and decay. It intersects with cancer biology, impacting progression, treatment sensitivity and prognosis. Platinum-based compounds are essential in cancer treatment, while intrinsic or acquired resistance poses a formidable challenge, limiting therapeutic efficacy. Recent breakthroughs have established a direct association between m6A RNA methylation and platinum resistance in various cancer types. This review summarized related studies, aiming to provide profound insights into the interplay between m6A-associated regulation and platinum-resistance mechanisms in cancer. It explores therapeutic approaches, including personalized treatments based on m6A profiles, guiding future research to enhance clinical strategies for oncological prognostic outcomes.
引用
收藏
页码：1221 / 1232
页数：12
相关论文
共 81 条
[1]   Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control [J].
Barbieri, Isaia ;
Tzelepis, Konstantinos ;
Pandolfini, Luca ;
Shi, Junwei ;
Millan-Zambrano, Gonzalo ;
Robson, Samuel C. ;
Aspris, Demetrios ;
Migliori, Valentina ;
Bannister, Andrew J. ;
Han, Namshik ;
De Braekeleer, Etienne ;
Ponstingl, Hannes ;
Hendrick, Alan ;
Vakoc, Christopher R. ;
Vassiliou, George S. ;
Kouzarides, Tony .
NATURE, 2017, 552 (7683) :126-+
[2]   Hakai is required for stabilization of core components of the m6A mRNA methylation machinery [J].
Bawankar, Praveen ;
Lence, Tina ;
Paolantoni, Chiara ;
Haussmann, Irmgard U. ;
Kazlauskiene, Migle ;
Jacob, Dominik ;
Heidelberger, Jan B. ;
Richter, Florian M. ;
Nallasivan, Mohanakarthik P. ;
Morin, Violeta ;
Kreim, Nastasja ;
Beli, Petra ;
Helm, Mark ;
Jinek, Martin ;
Soller, Matthias ;
Roignant, Jean-Yves .
NATURE COMMUNICATIONS, 2021, 12 (01)
[3]  
Cassidy J, 2000, INT J CLIN PRACT, V54, P399
[4]   The m6A methyltransferase METTL3 regulates autophagy and sensitivity to cisplatin by targeting ATG5 in seminoma [J].
Chen, Hanfei ;
Xiang, Yali ;
Yin, Yinghao ;
Peng, Jingxuan ;
Peng, Dongyi ;
Li, Dongjie ;
Kitazawa, Riko ;
Tang, Yuxin ;
Yang, Jianfu .
TRANSLATIONAL ANDROLOGY AND UROLOGY, 2021, 10 (04)
[5]   RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2 [J].
Chen, Mengnuo ;
Wei, Lai ;
Law, Cheuk-Ting ;
Tsang, Felice Ho-Ching ;
Shen, Jialing ;
Cheng, Carol Lai-Hung ;
Tsang, Long-Hin ;
Ho, Daniel Wai-Hung ;
Chiu, David Kung-Chun ;
Lee, Joyce Man-Fong ;
Wong, Carmen Chak-Lui ;
Ng, Irene Oi-Lin ;
Wong, Chun-Ming .
HEPATOLOGY, 2018, 67 (06) :2254-2270
[6]   Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism [J].
Chen, Ping ;
Liu, Xi-qiao ;
Lin, Xiang ;
Gao, Li-ying ;
Zhang, Shuo ;
Huang, Xuan .
MOLECULAR THERAPY-ONCOLYTICS, 2021, 20 :228-239
[7]   The Emerging Role of N6-Methyladenosine RNA Methylation as Regulators in Cancer Therapy and Drug Resistance [J].
Chen, Zhaolin ;
Hu, Ying ;
Jin, Le ;
Yang, Fan ;
Ding, Haiwen ;
Zhang, Lei ;
Li, Lili ;
Pan, Tingting .
FRONTIERS IN PHARMACOLOGY, 2022, 13
[8]   m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells [J].
Cui, Qi ;
Shi, Hailing ;
Ye, Peng ;
Li, Li ;
Qu, Qiuhao ;
Sun, Guoqiang ;
Sun, Guihua ;
Lu, Zhike ;
Huang, Yue ;
Yang, Cai-Guang ;
Riggs, Arthur D. ;
He, Chuan ;
Shi, Yanhong .
CELL REPORTS, 2017, 18 (11) :2622-2634
[9]   Chemical inhibitors make their RNA epigenetic mark [J].
Cully, Megan .
NATURE REVIEWS DRUG DISCOVERY, 2019, 18 (12) :892-894
[10]   N6-methyladenosine links RNA metabolism to cancer progression [J].
Dai, Dongjun ;
Wang, Hanying ;
Zhu, Liyuan ;
Jin, Hongchuan ;
Wang, Xian .
CELL DEATH & DISEASE, 2018, 9
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