Phosphoproteome reveals long-term potentiation deficit following treatment of ultra-low dose soman exposure in mice

被引：5

作者：

Long, Qi ^{[1
,2
]}

Zhang, Zhenpeng ^{[1
]}

Li, Yuan ^{[1
,4
]}

Zhong, Yuxu ^{[3
]}

Liu, Hongyan ^{[3
]}

Chang, Lei ^{[1
]}

Ying, Ying ^{[3
]}

Zuo, Tao ^{[1
,6
]}

Wang, Yong'an ^{[3
,7
]}

Xu, Ping ^{[1
,2
,4
,5
,6
]}

机构：

[1] Chinese Acad Med Sci, Inst Life, Res Unit Prote & Res & Dev New Drug, State Key Lab Prote,Beijing Proteome Res Ctr,Natl, Beijing 102206, Peoples R China

[2] Anhui Med Univ, Sch Basic Med, Hefei 230032, Peoples R China

[3] Acad Mil Med Sci PLA China, Inst Pharmacol & Toxicol, Toxicol & Med Countermeasures, Beijing 100850, Peoples R China

[4] Guizhou Univ, Med Coll, Dept Biomed, Guiyang 550025, Peoples R China

[5] China Med Univ, Sch Publ Hlth, Program Environm Toxicol, Shenyang 110122, Peoples R China

[6] Natl Ctr Prot Sci Beijing, 38 Sci Pk Rd, Beijing 102206, Peoples R China

[7] Inst Pharmacol & Toxicol, 27 Taiping Rd, Beijing 100850, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2023年 / 459卷

基金：

中国国家自然科学基金;

关键词：

Low-dose soman; Phosphoproteomics; EXPRESSION;

D O I：

10.1016/j.jhazmat.2023.132211

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Soman, a warfare nerve agent, poses a significant threat by inducing severe brain damage that often results in death. Nonetheless, our understanding of the biological changes underlying persistent neurocognitive dysfunction caused by low dosage of soman remains limited. This study used mice to examine the effects of different doses of soman over time. Phosphoproteomic analysis of the mouse brain is the first time to be used to detect

引用

页数：13

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