Intestinal Microbiota and miRNA in IBD: A Narrative Review about Discoveries and Perspectives for the Future

被引：18

作者：

de Oliveira, Ellen Cristina Souza ^{[1
]}

Quaglio, Ana Elisa Valencise ^{[2
]}

Magro, Daniela Oliveira ^{[3
]}

Di Stasi, Luiz Claudio ^{[2
]}

Sassaki, Ligia Yukie ^{[1
]}

机构：

[1] Sao Paulo State Univ UNESP, Med Sch, Dept Internal Med, Campus Botucatu, BR-18618970 Sao Paulo, Brazil

[2] Sao Paulo State Univ UNESP, Inst Biosci, Dept Biophys & Pharmacol, Lab Phytomed Pharmacol & Biotechnol PhytoPharmaTec, BR-18618689 Sao Paulo, Brazil

[3] State Univ Campinas UNICAMP, Fac Med Sci, Dept Surg, BR-13083970 Campinas, SP, Brazil

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 08期

关键词：

intestinal microbiota; microRNA; dysbiosis; ulcerative colitis; Crohn's disease; inflammatory bowel; INFLAMMATORY-BOWEL-DISEASE; INVASIVE ESCHERICHIA-COLI; GUT MICROBIOTA; EPITHELIAL-CELLS; FECAL MICRORNAS; EXPRESSION; DYSBIOSIS; HEALTH; REGULATORS; BIOMARKERS;

D O I：

10.3390/ijms24087176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC) and comprises a chronic gastrointestinal tract disorder characterized by hyperactive and dysregulated immune responses to environmental factors, including gut microbiota and dietary components. An imbalance of the intestinal microbiota may contribute to the development and/or worsening of the inflammatory process. MicroRNAs (miRNAs) have been associated with various physiological processes, such as cell development and proliferation, apoptosis, and cancer. In addition, they play an important role in inflammatory processes, acting in the regulation of pro- and anti-inflammatory pathways. Differences in the profiles of miRNAs may represent a useful tool in the diagnosis of UC and CD and as a prognostic marker in both diseases. The relationship between miRNAs and the intestinal microbiota is not completely elucidated, but recently this topic has gained prominence and has become the target of several studies that demonstrate the role of miRNAs in the modulation of the intestinal microbiota and induction of dysbiosis; the microbiota, in turn, can regulate the expression of miRNAs and, consequently, alter the intestinal homeostasis. Therefore, this review aims to describe the interaction between the intestinal microbiota and miRNAs in IBD, recent discoveries, and perspectives for the future.

引用

页数：20