Municipal solid waste (MSW) landfills using leachate recirculation optimize the waste stabilization process by providing nutrition and moisture for biological activity. However, the leachate recirculation creates an environment with complex processes due to accelerated biodegradation and generated heat. Additionally, different timing in waste placement and the heterogeneous nature of MSW cause significant variations in properties throughout the intercalated layers. In this study, a settlement framework model employing Thermal-Hydraulic-Mechanical-Biochemical processes is proposed, which considers multiple MSW properties including temperature, pH, and saturation. The framework model includes a modified Cam-clay model to simulate short-term settlement and adopts mechanical and biological creep models for long-term settlement estimation. A long-term biological creep model that uses a single decay rate constant is revised to account for environmental factors such as temperature, pH, and saturation in estimating MSW decay rates. The framework model was calibrated using the data of large-scale column experiments, which were conducted at different temperatures and saturation conditions considering biodegradation rates. Also, an MSW placement strategy was developed to consider the effect of different waste layer placement timing in the progression of MSW landfill total settlement. The modeling framework was validated using settlement data from a landfill in Canada. The results showed that temperature and saturation have a significant influence on MSW settlement and therefore should be considered in MSW landfill settlement prediction models.