Diagnosis and management of post-transplant lymphoproliferative disease following solid organ transplantation in children, adolescents, and young adults

被引：16

作者：

Rubinstein, Jeremy ^{[1
,2
]}

Toner, Keri ^{[3
,4
]}

Gross, Thomas ^{[5
]}

Wistinghausen, Birte ^{[3
,4
,6
]}

机构：

[1] Univ Cincinnati, Dept Pediat, Coll Med, Cincinnati, OH USA

[2] Cincinnati Childrens Hosp Med Ctr, Canc & Blood Dis Inst, Div Oncol, 3333 Burnet Ave,MLC 7018, Cincinnati, OH 45229 USA

[3] Childrens Natl Hosp, Ctr Canc & Blood Disorder, Washington, DC USA

[4] Childrens Natl Hosp, Ctr Canc & Immunol Res, 111 Michigan Ave NW, Washington, DC 20010 USA

[5] Univ Colorado, Childrens Hosp Colorado, Dept Pediat, Sch Med, Box 115-AP,Rm C3404, Aurora, CO 80045 USA

[6] Childrens Natl Hosp, Ctr Canc & Blood Disorders, 111 Michigan Ave NW, Washington, DC 20010 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2023年 / 36卷 / 01期

关键词：

Post-transplant lymphoproliferative disease; Epstein-Barr virus; Solid organ transplantation; Adoptive immunotherapy; EBV-Specific T-cell therapy; EPSTEIN-BARR-VIRUS; LOW-DOSE CHEMOTHERAPY; LIVER-TRANSPLANTATION; HODGKIN LYMPHOMAS; CELL LYMPHOMAS; PTLD INCIDENCE; T-CELLS; DISORDER; EBV; RECIPIENTS;

D O I：

10.1016/j.beha.2023.101446

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Post-transplant Lymphoproliferative Disease (PTLD) remains a major complication of solid organ transplantation (SOT) in pediatric patients. The majority are Epstein-Barr Virus (EBV) driven CD20+ B-cell proliferations responsive to reduction to immunosuppression and anti-CD20 directed immunotherapy. This review focusses on the epidemiology, role of EBV, clinical presentation, current treatment strategies, adoptive immunotherapy and future research in EBV + PTLD in pediatric patients.

引用

页数：10

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