Positive changes to written language following phonological treatment in logopenic variant primary progressive aphasia: Case report

被引:1
作者
Nickels, Katlyn [1 ]
Beeson, Pelagie M. [1 ,2 ]
Rising, Kindle [1 ]
Jebahi, Fatima [1 ]
Kielar, Aneta [1 ]
机构
[1] Univ Arizona, Dept Speech Language & Hearing Sci, Tucson, AZ 85721 USA
[2] Univ Arizona, Dept Neurol, Tucson, AZ USA
来源
FRONTIERS IN HUMAN NEUROSCIENCE | 2023年 / 16卷
关键词
case report; logopenic variant primary progressive aphasia; phonological treatment; written language; tDCS; DIRECT-CURRENT STIMULATION; LEXICAL RETRIEVAL TREATMENT; POSTSTROKE APHASIA; TEST SCORE; PATTERNS; BRAIN; INTERVENTION; DYSGRAPHIA; TDCS; INDIVIDUALS;
D O I
10.3389/fnhum.2022.1006350
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Phonological impairment contributes to deficits in repetition and spoken naming in logopenic variant Primary Progressive Aphasia (lvPPA), but weakened phonology can also affect written language skills. In this experimental case report, we demonstrate phonological text agraphia in a 71-year-old woman in the early stages of lvPPA that undermined her ability to write meaningful, grammatical sentences. We investigated the therapeutic value of a rigorous treatment protocol to strengthen phonological manipulation skills coupled with transcranial direct current stimulation (tDCS). Intervention took place 5 days a week for 2 weeks with active tDCS, followed by a 2-month rest period, and then a second period of phonological treatment with sham tDCS. Over the course of treatment, our participant demonstrated improved phonological transcoding and manipulation skills as well as marked improvement in the proportion of grammatically well-formed, meaningful written narratives. Improvements in spelling and letter selection were also observed. Treatment gains were documented during phonological intervention in both active tDCS and sham treatment phases and were maintained 2 months after the conclusion of intervention. Importantly, improvements were observed in the context of a progressive disorder. These data present compelling evidence regarding the impairment-based approach that targets compromised phonological skills, presenting opportunity for improving functional written communication skills relevant to the everyday lives of individuals with lvPPA.
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页数:11
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