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Radboud Univ Nijmegen Med Ctr, Radboud Inst Hlth Sci, Dept Primary & Community Care, Geert Grootepl 21,Postbox 9101, NL-6500 HB Nijmegen, Netherlands Radboud Univ Nijmegen Med Ctr, Radboud Inst Hlth Sci, Dept Primary & Community Care, Geert Grootepl 21,Postbox 9101, NL-6500 HB Nijmegen, Netherlands