Rapid emergence of appetite and hunger resulting in weight gain and improvement of eating disorder symptomatology during and after short-term off-label metreleptin treatment of a patient with anorexia nervosa

被引：20

作者：

Gradl-Dietsch, Gertraud ^{[1
,4
]}

Milos, Gabriella ^{[2
]}

Wabitsch, Martin ^{[3
]}

Bell, Rebecca ^{[1
]}

Tschoepe, Franziska ^{[1
]}

Antel, Jochen ^{[1
]}

Hebebrand, Johannes ^{[1
]}

机构：

[1] Univ Duisburg Essen, Univ Hosp Essen, Dept Child & Adolescent Psychiat, Essen, Germany

[2] Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat Med, Zurich, Switzerland

[3] Univ Hosp Ulm, Dept Pediat & Adolescent Med, Div Pediat Endocrinol & Diabet, Ulm, Germany

[4] Univ Duisburg Essen, Univ Hosp Essen, Dept Child & Adolescent Psychiat, Wickenburgstr 21, D-45147 Essen, Germany

来源：

OBESITY FACTS | 2023年 / 16卷 / 01期

关键词：

LEPTIN LEVELS; SERUM LEPTIN; GONADOTROPIN; MECHANISMS; GENDER; STAGE;

D O I：

10.1159/000527386

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Off-label treatment of a 15-year-old female patient with anorexia nervosa with human recombinant leptin (metreleptin) for nine days was associated with self-reported increments of appetite and hunger resulting in rapid weight gain, substantial improvement of eating disorder cognitions and of depression. The results further substantiate the effects of metreleptin on both AN and depression. We contrast these results with the widespread view that leptin is an anorexigenic hormone. Randomized controlled trials are warranted to confirm the described effects.

引用

页码：99 / 107

页数：9