Novel strategies in nephrology: what to expect from the future?

被引：8

作者：

Copur, Sidar ^{[1
]}

Tanriover, Cem ^{[1
]}

Yavuz, Furkan ^{[1
]}

Soler, Maria J. ^{[2
,3
]}

Ortiz, Alberto ^{[4
,5
]}

Covic, Adrian ^{[6
,7
]}

Kanbay, Mehmet ^{[8
]}

机构：

[1] Koc Univ, Sch Med, Dept Med, Istanbul, Turkey

[2] Univ Autonoma Barcelona, Vall Hebron Univ Hosp, Dept Nephrol, Barcelona, Spain

[3] Vall Hebron Res Inst VHIR, Nephrol & Kidney Transplant Res Grp, Barcelona, Spain

[4] Univ Autonoma Madrid, Dept Med, Madrid, Spain

[5] IIS Fdn Jimenez Diaz, Madrid, Spain

[6] CI PARHON Univ Hosp, Nephrol Clin, Dialysis & Renal Transplant Ctr, Iasi, Romania

[7] Grigore T Popa Univ Med, Iasi, Romania

[8] Koc Univ, Sch Med, Dept Med, Div Nephrol, Istanbul, Turkey

来源：

CLINICAL KIDNEY JOURNAL | 2023年 / 16卷 / 02期

关键词：

artificial kidney; bioengineering; chronic kidney disease; induced pluripotent stem cells; xenotransplantation; MESENCHYMAL STEM-CELLS; ACUTE KIDNEY INJURY; WEARABLE ARTIFICIAL-KIDNEY; BIOARTIFICIAL KIDNEY; HEART-FAILURE; RENAL-FAILURE; SODIUM MRI; DISEASE; DIALYSIS; PROGRESSION;

D O I：

10.1093/ckj/sfac212

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic kidney disease (CKD) will become the fifth global case of death by 2040. Its largest impact is on premature mortality but the number of persons with kidney failure requiring renal replacement therapy (RRT) is also increasing dramatically. Current RRT is suboptimal due to the shortage of kidney donors and dismal outcomes associated with both hemodialysis and peritoneal dialysis. Kidney care needs a revolution. In this review, we provide an update on emerging knowledge and technologies that will allow an earlier diagnosis of CKD, addressing the current so-called blind spot (e.g. imaging and biomarkers), and improve renal replacement therapies (wearable artificial kidneys, xenotransplantation, stem cell-derived therapies, bioengineered and bio-artificial kidneys).

引用

页码：230 / 244

页数：15

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